Scientist, Regenerative Medicine - Immunology

ICR is researching ways to regenerate the aged immune system. Immune senescence and decline underlie many of the most devastating age‑related diseases. Our Regenerative Immunology program involves several approaches, including developing bone marrow‑engraftable iPSC‑derived hematopoietic stem cells (iHSCs) and implantable thymic organoids. With us, you’ll get to: Develop engraftment‑competent human iHSCs Design and execute independent research on iHSCs, examining quality control aspects of cell production, translational function and safety with emphasis on oncogenic landscape analyses and safety issues related to long‑term engraftment Derive and fully characterize different cell types from iHSCs, including designing assays to test their potentially improved function against aged HSCs Devise and test practical, innovative strategies to rejuvenate the aging human immune system, including testing interventions to combat thymic involution Please apply if you have: PhD or another advanced degree in Immunology or another biomedical science field Experience researching human hematopoietic stem cells and/or other aspects of immune regeneration Experience with iPSCs and iHSC‑derived cell types Expert knowledge in experimental therapeutics and the therapeutic pipeline of primary HSCs and iHSCs, with an emphasis on practical, actionable interventions to treat and prevent age‑related immune senescence and achieve immune regeneration/rejuvenation Extensive experience in bench molecular and small molecule biology, cell biology, immunology, hematology, hematopoiesis and bone marrow niche biology Ideally, you’ll also have: Expertise in and working knowledge of age‑related immune senescence and hematologic dysfunction General and working knowledge of aging biology, adult stem cells, regenerative and personalized medicine as well as gene therapy (AAV‑mediated) Experience with in vitro and in vivo models of immune‑senescence and regeneration And you’ll need: A friendly, easygoing personality The ability to work in the United States without sponsorship Salary Starting base pay range: $130,000/yr - $175,000/yr Starting additional compensation range: $7,500/yr - $17,500/yr Starting position title and compensation are commensurate with experience. #J-18808-Ljbffr Initial Therapeutics, Inc.