Scientist l, Biopharmaceutics

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology, and neuroscience, and products and services in our Allergan Aesthetics portfolio. Position Overview The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state-of-the-art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to advance candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross‑functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API), establish structure‑property‑performance correlations, and transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites, ensuring successful regulatory submissions. This scientist role focuses on developing and executing studies that characterize the biopharmaceutical properties of peptide and small molecule pipeline programs, providing critical data for developability and product performance decisions. Key Responsibilities Design, execute, troubleshoot, and interpret experiments related to biopharmaceutics properties of small molecules and peptides such as solubility, dissolution, permeability, stability, aggregation, precipitation, and formulation performance, as applicable. Generate high-quality data and maintain accurate, timely, and complete documentation of experimental procedures, results, and conclusions. Analyze and summarize data using appropriate scientific methods and communicate findings to project teams and functional stakeholders. Contribute to the assessment of candidate molecules and formulations by identifying key risks, opportunities, and data‑driven recommendations. Support development, optimization, and continuous improvement of experimental methods, workflows, and scientific capabilities. Maintain awareness of external scientific advances and incorporate relevant knowledge into project work where appropriate. Contribute to a collaborative, inclusive, and scientifically rigorous team environment. Qualifications Bachelor's degree or equivalent education with typically five years of experience, or master's degree or equivalent education with typically two years of experience in pharmaceutical or related industry. Preferred educational backgrounds include Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/Biomedical Engineering, Chemistry, and Materials Science. Fundamental understanding of biopharmaceutics in relation to drug absorption across routes of administration including solubility, biorelevant dissolution testing, permeability, ex vivo permeability assessment, and peptide aggregation. Familiarity and preferred hands‑on laboratory experience in in vitro assays and standard analytical techniques for physicochemical and biopharmaceutical property assessment, such as chromatography, differential scanning fluorimetry, rat intestinal perfusion, Ussing chambers, Franz diffusion cells, dissolution, X‑ray diffraction, thermal analysis, microscopy, biophysical characterization techniques, etc. Knowledge of preclinical and clinical formulation development principles relevant to chemically synthesized molecules across routes of administration. Ability to analyze data and draw scientifically sound conclusions. Demonstrated strong communication skills and ability to clearly communicate theories and concepts, influence others without authority, and drive technical excellence. Excellent self‑management skills, organizational skills, and attention to detail. Compensation & Benefits Compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of posting based on the job grade. Individual compensation paid within this range will depend on many factors including geographic location. Benefits include paid time off (vacation, holidays, sick leave), medical, dental, and vision insurance, and 401(k) to eligible employees. Opportunities to participate in short‑term incentive programs, subject to eligibility and company discretion. Equal Opportunity AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only – for more information visit US & Puerto Rico applicants seeking a reasonable accommodation can learn more at #J-18808-Ljbffr BioSpace