Senior Director, Lab-to-Product Platform and Operations Technology

Overview Alnylam is seeking a strategic and pragmatic technology leader to serve as Senior Director, Lab-to-Product Platform & Operations Technology , a role that owns the core digital platforms, services, lab computing environment, and operational technologies that power laboratory operations across Research, CMC, and Quality Control, as well as digital enablement of plant‑floor (shopfloor) operational technologies (OT). This scope extends beyond internal operations to include operational technology enablement, secure data exchange, workflow interoperability, and validated system readiness that support external execution partners—including CROs, external research labs, development collaborators, contract testing labs, and external manufacturing partners. This role is focused on operational platforms—the systems, integrations, partner connectivity, validated interfaces, computing environments, and services that ensure labs, plants, and external partners run reliably, compliantly, and efficiently. Scientific research platforms and enterprise manufacturing systems (e.g., MES and supply chain planning) are owned by their respective teams. This role ensures seamless interoperability, operational data flow, OT enablement, and validated integration frameworks across internal and external environments while maintaining clear ownership boundaries. This role is responsible for building and operating a modern Lab-to-Product operational platform that connects experiment execution, sample and materials workflows, QC testing, and plant operations—regardless of whether those activities occur internally or through external partners. This hybrid role is based primarily in Cambridge, MA, with regular engagement at our Cambridge labs and Norton/Alewife manufacturing sites, and direct interaction with external execution partners. Key Responsibilities 1. Own and operate core lab, plant, and external partner operational platforms Lead the digital capabilities that support lab operations across Research, CMC, and QC, including LIMS, ELN/LES, sample & inventory management, registration, lab automation enablement, instrument integration, lab computing, lab system validation, and operational data capture. Oversee plant‑floor operational technologies (OT) such as equipment/instrument connectivity, environmental and facility monitoring interfaces, materials tracking, barcode/RFID data capture, and automated data collection (excluding MES and supply chain systems). Enable operational technology connectivity, workflow interoperability, and validated data exchange with CROs, external research labs, development partners, contract testing labs, and external manufacturers. Support validated data handoffs, sample/material traceability, workflow tracking, and operational interfaces across hybrid (internal + external) execution models. Ensure reliability, compliance, validated state, lifecycle management, and service continuity across internal systems and partner‑connected operational interfaces. Oversee lab/operational system validation activities in partnership with Quality to maintain GxP compliance and data integrity across all execution environments. 2. Build the Lab-to-Product Platform (Internal + External Execution Model) Architect and deliver the operational platform that connects experiment execution sample workflows QC testing plant operational activities external execution and release workflows. Provide reusable platform components including metadata standards, workflow modules, instrument connectors, validated integration frameworks, and operational data pipelines that external partners can adopt or interface with. Ensure seamless interoperability with: Scientific platforms owned by ReDev Technology Manufacturing/enterprise systems owned by Manufacturing/CMC/Supply Chain Technology External research, development, QC, and manufacturing partner systems Establish secure, scalable, validated patterns for partner connectivity (e.g., APIs, secure file exchange, partner portals, event/data streams). 3. Lead a high‑performing operations-focused technology team Build and develop talent and capabilities across product management, engineering/architecture, lab computing support, instrument connectivity, and operational platform engineering. Define support, governance, onboarding, and escalation models for external partners, including SLAs and service continuity plans in collaboration with ReDev and TOQ. Drive a culture centered on operational excellence, validation rigor, compliance, accountability, and pragmatic problem‑solving. Establish standards, governance, and best practices for lab/plant operational technology, including lab system validation frameworks. 4. Deliver robust operational data integration Work closely with the Data & AI organization to ensure operational data—including external partner‑generated data— is structured, contextualized, and AI‑ready. Implement consistent metadata, data capture, and validated interface practices across internal and external operations. Enable cross‑system visibility into workflows, materials, samples, and processes across internal labs, plants, and external partner networks. 5. Partner deeply across the enterprise and external ecosystem Collaborate with ReDev Technology, Manufacturing/CMC/Supply Chain Technology, Quality, Tech Operations, Data/AI, Infrastructure, and Security to ensure cohesive integration and operational excellence. Partner with ReDev and TOQ to define and support the digital operating model for CROs, external labs, contract testing labs, and external manufacturers. Maintain clear ownership boundaries while ensuring the operational platform enables distributed execution. Serve as a trusted partner to scientific, operational, and quality stakeholders—internally and externally. Qualifications Required Bachelor's degree in Computer Science, Engineering, Life Sciences, or related field (or equivalent experience). 15+ years of progressive leadership experience in laboratory informatics, scientific operations, OT/plant‑floor (shop floor) automation enablement, or manufacturing operational technology in biotech/pharma. Deep expertise with lab operations systems (e.g., LIMS, ELN/LES, sample/inventory management, workflow orchestration), lab computing environments, instrument integration, and validated interfaces. Experience supporting operational workflows across internal and external networks, including CROs, external research labs, contract testing labs, and/or external manufacturers. Strong understanding of GxP, Computer System Validation (CSV), data integrity, interoperability, and operational data management. Experience leading product management and engineering/architecture teams in regulated and non‑regulated environments. Proven track record delivering enterprise‑scale operational platforms with measurable impact. Exceptional communication, influence, and stakeholder‑management skills. Ability to balance long‑term strategy with pragmatic execution. Preferred Advanced degree in Computer Science, Engineering, or Life Sciences. Experience supporting RNAi, oligonucleotide, or other advanced modality development or manufacturing. Familiarity with modern integration architectures (APIs, event‑driven patterns), lab automation frameworks, OT/plant‑floor technologies, and emerging AI‑driven automation. Experience in environments where R&D, CMC, QC, Manufacturing, and external partners depend on shared operational platforms and validated systems. U.S. Pay Range $226,800.00 - $306,800.00 The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity). Benefits Alnylam's robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together. Equal Employment Opportunity At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an e‑Verify Employer. #J-18808-Ljbffr Alnylam Pharmaceuticals