Director/Associate Director, Toxicology
$235k - $315kCalico LLC
Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking an accomplished and motivated individual to step into the role of Nonclinical Safety Leader within our Toxicology and Pathology team. This leader will collaborate with innovative and diverse scientists and play a pivotal role in advancing Calico's preclinical pipeline and development portfolio. The ideal candidate will leverage deep and proven expertise in toxicology to provide leadership for discovery and development projects, with flexibility to specialize or work across stages of development, therapy areas, and modalities. Responsibilities:
The estimated base salary range for this role is $235,000 - $315,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses
- Act as a Nonclinical Safety representative and Subject matter expert representing toxicology on project teams to support on early- and late-stage project development teams
- Proactive risk assessment of potential target pharmacology and chemotype-related toxicity issues, preparing safety strategies, and designing and implementing studies to drive toxicology plans
- Provides scientifically and strategically sound nonclinical development plans to management and development teams
- Oversee the proper design and timely reporting of toxicity studies (GLP/nonGLP), including single- and repeat-dose toxicity, investigative toxicity, and other toxicity studies as required
- Analyze and interpret toxicological data, ensuring accuracy and compliance with regulatory standards, and communicate toxicology findings to management and development teams
- Be accountable for authoring and review of global regulatory nonclinical documents such as CTD sections for INDs and NDAs, IBs, PIPs and health authority responses (briefing books) to support clinical trials and drug registration globally
- Contribute to global regulatory submissions (e.g., IBs, Briefing Books, INDs, NDA/BLAs) and interact with regulatory authorities worldwide on issues of nonclinical safety evaluation
- Represent Calico in external scientific and regulatory collaborations, committees and consortia
- Participate in nonclinical safety risk assessments for due diligence of potential external opportunities
- Ensure compliance with Good Laboratory Practice, Standard Operating Procedures, and study protocols in conducting nonclinical studies, when applicable
- PhD in Toxicology or related scientific discipline with 8+ years of regulatory toxicology/development experience
- Board certification (e.g. Diplomate of the American Board of Toxicology (DABT))
- Demonstrated and proven track record of successfully delivering small and large molecule candidates that have achieved preclinical candidate nomination and progressed into clinical development as the project toxicologist
- Experience in representing toxicology/nonclinical safety on multi-disciplinary project teams
- Experience in conducting or overseeing nonclinical studies with small and large molecules
- Extensive knowledge of GLP principles and FDA/ICH guidelines
- Experience in conducting due diligence of nonclinical safety data
- Self-motivated, enthusiastic, and highly adaptable with the ability to quickly identify project challenges and pivot strategies in a fast-paced environment
- Exceptional oral communication and writing skills, with record-keeping and data organization skills
- Must be willing to work onsite at least 4 days a week
- Experience in developing and applying advanced in vitro models (co-culture systems, iPS-derived cells, spheroids, organoids, organ-on-a-chip) or new approach methodologies (NAMs) to address mechanistic/investigative toxicology questions
The estimated base salary range for this role is $235,000 - $315,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses
Vacancy posted 4 days ago
Similar jobs that could be interesting for youBased on the Director/Associate Director, Toxicology in South San Francisco, CA vacancy
$171k - $223k
...patients.Leads nonclinical safety strategy for development programs, advancing assets from discovery through clinical stages. Shapes toxicology approaches, interprets complex data, and influences program decisions to ensure patient safety and regulatory success. Serves as...SuggestedLocal area$175k - $200k
...Associate Director, Biostatistics Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound...SuggestedInterim roleWork at officeLocal areaLyell Immunopharma
South San Francisco, CA4 days ago$159.6k - $251.2k
**Job Description**The Associate Director, Business Development & Licensing (BD&L) Discovery Transactions will be part of a seasoned team of transaction leads located in Rahway, NJ, West Point, PA, Cambridge, MA, and South San Francisco, CA.The successful candidate will...SuggestedContract workFor contractorsWork experience placementLocal areaWorldwideRelocationVisa sponsorshipFlexible hours$159.6k - $251.2k
Job Description The Associate Director, Business Development & Licensing (BD&L) Discovery Transactions will be part of a seasoned team of transaction leads located in Rahway, NJ, West Point, PA, Cambridge, MA, and South San Francisco, CA. The position will be based in...SuggestedContract workWork experience placementRelocationVisa sponsorship$154k - $300k
Analytical Characterizations October 2025 Department: Technology Position Summary: Soleil is seeking an expert and engaged Associate Director / Director , Analytical Lead to head our analytical and biophysical characterization efforts within the Protein Sciences group...SuggestedTemporary workFlexible hours$160k - $185k
...improve the lives of patients and families affected by devastating neurological disorders. For more information, please visit The Associate Director, G&A Applications will lead the delivery, and continuous improvement of enterprise applications that power Encoded’s Finance,...Contract workWork experience placementWork at officeRelocation$182.75k - $275k
...problems and push to achieve what’s possible, one breakthrough at a time. About this opportunity: At Freenome, we are seeking an Associate Director, Product Management to help grow the Freenome Product Management team. The ideal candidate is someone who seeks to define and...Local area$170.54k - $216.36k
Initial Therapeutics, Inc. is seeking a Senior Manager / Associate Director of Computer Systems Assurance in Brisbane, CA. This role will involve overseeing the CSA program and ensuring compliance with regulatory expectations while validating SaaS GxP systems. The ideal...- ...Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything... ...the GPL as the lead GPM on early stage assets. The Associate Director PM will provide content expertise to the timing, costs, and resources...Hourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work
$190k - $280k
...clinic. Lycia is headquartered in South San Francisco. Visit for more information. Position Lycia Therapeutics is seeking a Director or Associate Director of Clinical Science who will play a critical role in the design, execution, and analysis of clinical trials of...Work at officeFlexible hours2 days per week3 days per week$195k - $200k
...inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description We are seeking an experienced Associate Director, External Communications to join our Corporate Communications team. In this key role, you will develop and execute...- A leading biotech firm in South San Francisco seeks an Associate Director / Director, Analytical Lead to manage analytical characterization efforts within Protein Sciences. The ideal candidate will have 12+ years of experience in antibody characterization and a Ph.D. in...
$170.54k - $193.49k
...treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Senior Manager / Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems...- ...oncogenes in human tumors. For more information visit BBOTx.com.Who You AreThis is an exciting opportunity for a highly motivated **Associate Director, Clinical Supply Chain** with a strong background in global clinical supply chain. We are looking for a talented and...Contract workRemote work
Bbot
South San Francisco, CA3 days ago $160k - $185k
Encoded Therapeutics in South San Francisco is seeking an Associate Director, G&A Applications to lead the delivery and improvement of enterprise applications in Finance, Procurement, and HR. The ideal candidate will have 8+ years in G&A applications, preferably in life...$215.54k - $260.82k
Associate Director, Clinical Regulatory page is loaded## Associate Director, Clinical Regulatorylocations: South San Franciscotime type: Full timeposted on: Posted 4 Days Agojob requisition id: R-1479Neurodegenerative diseases are one of the largest medical challenges...Work experience placementLocal area$170k - $210k
...cell therapy on‑demand, more reliably, and at greater scale to more patients. About the role We are seeking a highly motivated Associate Director, Quality Data Science to work in this exciting new area of allogeneic cell therapy. In this role, you will report to the head...Local area- Associate Director / Director, Analytical Development Location: Brisbane, CA (Onsite) About BreezeBio BreezeBio is an early-stage biotech company building a next-generation delivery platform for genetic medicines. Our team integrates chemistry, payload design, formulation...
$186k - $225k
...and pulmonary conditions. Position Summary Reporting to the Director of Quality Assurance, this role is responsible for providing strategic... ...development and manufacturing organizations (CDMOs). The Associate Director will serve as the primary QA point of contact for DS...Contract workWork at office- Atara Biotherapeutics: Director, Preclinical Sciences Atara Biotherapeutics mission is to develop novel treatment options for patients... ...designing preclinical pharmacology, pharmacokinetic, and toxicology IND enabling studies, and also managing scientific collaborations...
$137.94k - $206.91k
...of each study. Can you anticipate laboratory risks before they materialize and simplify the path from sample to insight? The Associate Director, Study Management - Central Laboratory Operations (ADSM Central Lab) is a core member of the global study team and acts as the...Full timeTemporary workWork at officeFlexible hoursShift work$187k - $229k
...Associate Director, Accounting South San Francisco, CA The Position The Finance team is looking for an Associate Director, Accounting. As the Associate Director, Accounting, you sit at the center of our company's financial integrity and operational execution....$180k - $200k
...Manager: Lead data science activities at the study level; operate as a hands‑on contributor delivering analyses and tools. Associate Director: Provide program-level oversight across multiple studies; influence data science strategy and cross‑functional alignment. Contribute...Remote work$199k - $244k
The Opportunity Join Maze Therapeutics as an Associate Director, Regulatory Affairs , where you will play a critical role in advancing our clinical‑stage programs by providing regulatory expertise and executional leadership. As a key member of the development team, you...3 days per week$199k - $244k
Initial Therapeutics, Inc. seeks an Associate Director, Regulatory Affairs to lead and manage regulatory affairs for clinical-stage programs. You will collaborate on global regulatory activities and be responsible for preparing submissions and facilitating authority interactions...3 days per week- ...international regulatory requirements. Build strong collaborative relationships with PST Therapeutic Area leadership and Group Medical Directors, as well as senior leaders in Epidemiology and Medical Aesthetics & Device Safety, Clinical Trial Safety & Insights. Provide...Temporary workWork at office
- Job Description The Associate Director, Regulatory Strategic Planning, is responsible for successfully delivering project management capabilities for highly complex, cross‑functional teams within and across the Regulatory Affairs organization. The individual combines knowledge...Local area
$170k - $210k
...available cell therapy on‑demand, more reliably, and at greater scale to more patients. About the role Allogene is seeking an Associate Director, Regulatory Affairs within the Global Regulatory Affairs and Clinical Quality organization who will manage worldwide...Contract workLocal areaRemote workWorldwide$171k - $223k
...marketing safety data to support emerging risk assessment and program-level benefit-risk evaluation in partnership with Safety Science directors and cross-functional development teams. Drives development of safety analyses and contributes to safety strategy for programs....Full timeLocal area$179k - $200k
...encourage you to apply. Learn more about our commitment to diversity, equity, inclusion, and our company culture! Position: The Associate Director of Clinical Trial Management will contribute to the development and implementation of clinical studies. Responsibilities...Full timeContract workRemote workFlexible hours
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director/Associate Director, Toxicology. Be the first to apply!
Related searches
- director of culinary South San Francisco, CA
- director of community outreach South San Francisco, CA
- pathology director South San Francisco, CA
- director of aviation South San Francisco, CA
- director continuous improvement South San Francisco, CA
- director estimating South San Francisco, CA
- director of benefits South San Francisco, CA
- director infection prevention South San Francisco, CA
- director of automation South San Francisco, CA
- director of fulfillment South San Francisco, CA