Senior Research Scientist Platform Biology

We have an exciting opportunity for an experienced scientist to join our biochemical and biophysical assay team in Platform Biology. The selected candidate will participate in assay design, implementation, and data quality control across our programs in ligand discovery and targeted protein degradation. Ideally, the candidate will be experienced in Surface Plasmon Resonance (SPR) and have broad expertise covering various biochemical and biophysical assays and instrumentation. This position will drive assay development, execution and provide the key, critical data necessary to advance programs towards targeted protein degradation in highly disease relevant projects to help human health. This position reports to the Senior Research Investigator, Degrader Mechanisms Group in our Platform Biology department and will be located at our headquarters in New Haven, CT. Principal Responsibilities Biophysical assay design and execution across different modalities, with a focus on SPR and including TSA, DSF, and MST. Evaluation and implementation of cellular ligand binding and characterization techniques (such as BRET, NanoBRET and other high-throughput cellular target engagement assays) Biochemical assay design, assay development and execution across different plate-based modalities, such as TR‑FRET, FP, and alphaLISA. Mechanism of action studies of ligand binding and degrader characterization utilizing cellular and biochemical assays. Manage CRO outsourcing of biochemical and biophysical assays such as ASMS, as necessary. Data capture, database upload, and presentation of assay development and trouble‑shooting data in a clear manner in a group meeting setting. Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs. Troubleshoot through technical and scientific challenges in order to deliver critical data. Serve as Platform Lead scientist for assigned projects. Communicate and coordinate Platform activities, and be primary point of contact for biochemical and biophysical needs for assigned projects across wider project teams. Apply excellent organizational and prioritization skills; analyze data using strong background in biochemistry and biophysics and troubleshoot through technical and scientific challenges in order to deliver critical data. Organize experimental results to be shared with project teams; maintain clear experimental records using ELN (electronic lab notebook). Qualifications Skilled, motivated and productive bench scientist with excellent communication and organizational skills who works effectively in a dynamic team setting. Strong background in protein biochemistry and biophysics; expertise in protein‑ligand interactions, induced proximity approaches, or cellular ligand interactions are pluses. Demonstrated experience in experimental design, execution, and data analysis for protein‑protein and protein‑ligand interactions using biophysical and/or biochemical techniques; experience with cellular ligand target engagement techniques is a plus. Demonstrated experience with SPR; additional experience with plate‑based assay formats and instrumentation across biochemical and biophysical platforms including TR‑FRET, FP, alphaLISA, ASMS, and TSA, are pluses. Exhibited proficiency in problem solving and analytical thinking skills. Experience outsourcing CRO work and managing projects and timelines. Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for a current or future VISA sponsorship. The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Education BS with 7+ years of pharma/biotech or academic experience, or PhD with 2+ years of pharma/biotech or academic experience, with a focus on biophysical and/or biochemical assay execution. Background in protein‑protein and protein‑ligand interactions and in drug discovery. Background in the protein degradation, induced proximity, and ubiquitin proteasome system are pluses. Additional training in complimentary biophysical, biochemical, and targeted protein degradation techniques will be provided as needed. Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. #J-18808-Ljbffr Arvinas