Senior Manager, Statistical Programming

About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. Led by Tassos Giannakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020. We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day. Position Title: Senior Manager, Statistical Programming Department: Clinical Data Sciences & Analytics Reports To: Head of Statistical Programming Location: South San Francisco, CA or Princeton, NJ – On-site 4 days per week (Mon to Thurs) Job Overview: The Senior Manager of Statistical Programming will be responsible for leading Statistical Programming activities. It involves hands‑on implementation of statistical analyses using SAS/R, as well as performing quality reviews of deliverables, both for in-house analyses and outsourced programming tasks. This position serves as a critical bridge between Biostatistics and Clinical Data Management (CDM), ensuring the development of CRFs and the delivery of high-quality clinical data. Additionally, this position will play an important role in helping establish SOPs and programming standards and also build our SCE platform. ESSENTIAL DUTIES AND RESPONSIBILITIES Key Project Responsibilities: Provides programming leadership and oversee study to compound-level programming deliverable in collaboration with the Stats lead and cross-functional teams. Serve as the lead programmer to reviews SAP, Data Presentation Plan, Table Shell to align with project objectives and ensures clarity and completeness of programming assumptions and requirements. Lead programming team to produce and/or validate SDTM, ADaM and TLF, for CSR and regulatory requests, publication needs, and ad-hoc analyses. Manage CROs and contractors, ensuring compliance, quality of deliverables, timelines, and budget adherence. Collaborate with biostatisticians and clinical development colleagues to develop/review TLF shells, SDTM, and ADaM specifications. Work closely with Data Management and Biostatistics teams to ensure the accuracy of final databases, analyses, and reports. Develop global tools, such as macros or graphical user interface applications, to enhance the efficiency and capacity of the Statistical Programming team. Develops robust program to create define.xml, Leads the NDA eSubmission package preparation. Assist Biometric in building the statistical computing environment (SCE) platform, including designing folder structure and managing access control. Initiative Responsibilities: Under guidance from Head of Statistical Programming and Compound PL, implement innovative strategies and technologies to enhance programming processes. Working with manager, establish Statistical Programming standard and deploy programming strategies, specifications and programmed analysis. Proactively plan, implement, and identify issues/risks and provide remediation strategies to improve programming capability. Qualifications and Preferred Skills Education: Master’s degree in Statistics/Biostatistics, Mathematics, Computer Science, or a related field. Experience and Skill Set: Minimum of 6 years statistical programming experience in the pharmaceutical, biotech or CRO clinical trial environment. Advanced SAS programming skills. Extensive Hands‑on experience with SDTM, ADaM, TLF programming Proficient knowledge in the implementation of CDISC standards (SDTM, ADaM) and regulatory submission requirements. Good knowledge of drug development process, study design, statistical methodology, regulatory guidance, statistical concepts, and medical terminology. Broad expertise in statistical programming and in developing computing strategies. In-depth understanding of CDISC standards including SDTM and ADaM models and extensive experience of their implementation in clinical trials. Demonstrated proficiency in using SAS/R to produce analysis datasets and TFLs. Knowledge of data validation, define.xml generation using Pinnacle 21. Results orientated with proven problem‑solving skills and a strong interest in ongoing learning. Excellent communication and collaboration skills, with the ability to work closely with cross‑functional teams Experience managing outsourced programming activities and overseeing deliverables from CROs and contractors. Adaptable and thrives in a fast‑paced, startup environment while managing multiple priorities effectively. Experience with regulatory audits and inspections and IR (e.g., FDA, PMDA, NMPA, EMA) is a strong advantage. Exact Compensation may vary based on skills, experience and location. Pay range $172,000 - $234,000 USD Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self‑identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Kardigan’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service‑connected disability. A "recently separated veteran" means any veteran during the three‑year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Voluntary Self-Identification of Disability Form CC‑305 Page 1 of 1 OMB Control Number 1250‑0005 Expires 04/30/2026 Why are you being asked to complete this form? We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at How do you know if you have a disability? A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention‑deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete. #J-18808-Ljbffr