Technical Development Principal Scientist / Engineer

The PositionA healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche group!In Pharma Technical Development (PTD), we actively collaborate and develop creative technical solutions to efficiently transform scientific ideas into products. Our mission is to reliably deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication and mutual respect, and contributes every single day, continuously improving what it does.The OpportunityA Principal Engineer / Scientist position is available in Genentech and Roche’s Pharma Technical Development organization within the Cell Culture and Bioprocess Operations (CCBO) group.Job Responsibilities:Serve as a key team member in developing scalable, robust, efficient, and sustainable microbial (E. coli) processes for biologics production.Represent the function on cross-functional project teams, collaborating with leads on all aspects of CMC project deliverables.Stay informed on industry trends and advancements in microbial process technology.Collaborate with representatives across research, manufacturing, quality, and regulatory functions.Author sections of regulatory filings and prepare responses for Health Authority Q&A.Serve as a functional ambassador to advocate for and influence stakeholders on new technology implementation.Who you areRequirements:Advanced degree in Chemical Engineering or a related discipline, with a Master’s degree and 8+ years of relevant experience, or a Ph.D. with 4+ years of relevant experience in E. coli or other microbial process development.Advanced technical experience supporting E. coli or other microbial process development, characterization, and validation activities.Proven ability to work independently, challenge the status quo, manage multiple projects, prioritize and delegate effectively, adapt quickly to changes, and collaborate on cross-functional teams.Strong written and verbal communication skills.Preferred:Biopharma industry experience.Experience developing and implementing models and leveraging AI-based tools for microbial process development and optimization.Experience in microbial media development.Relocation benefits are available for this job posting.The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Job SummaryJob number: 202609-124845Date posted : 2026-10-07Profession: Manufacturing & EngineeringEmployment type: Full time