Senior Product Manager, AI

Company Description Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook. Position Summary: The Senior Product Manager, AI will lead the delivery and evolution of Guardant’s AI product roadmap across both internal operations and customer-facing experiences. This role is responsible for driving conversational, generative, agentic, and predictive AI solutions that improve operational efficiency, scale service capacity, and elevate provider and patient engagement through intuitive, seamless, and cohesive customer experiences. Partnering with a diverse cross-functional team, the Senior PM will ensure AI investments align with Guardant’s strategic priorities while delivering end-to-end experiences that are consistent, trusted, and user-centric across every touchpoint. This individual will play a key role in defining and optimizing CX flows, ensuring AI capabilities are thoughtfully integrated into workflows to reduce friction, simplify complex interactions, and create meaningful experiences for providers, patients, and internal teams alike. The ideal candidate brings deep knowledge of AI technologies, proven experience translating business and user needs into scalable product solutions, and a strong track record of driving cross-functional alignment across product, design, engineering, operations, and customer-facing teams. Success in this role requires both strategic thinking and strong execution, with the ability to influence stakeholders and champion a high-quality customer experience throughout the product lifecycle. Essential Duties and Responsibilities: Product Roadmap Partner with stakeholders and Engineering to define and execute the roadmap for Screening AI solutions. Prioritize high-impact use cases that scale operations, improve provider/patient experiences, and align with Guardant’s strategic objectives. Stay ahead of AI and healthcare technology trends to ensure competitive and compliant solutions. Product Delivery Lead the full product lifecycle from ideation through launch, adoption, and iteration. Translate business needs into clear product requirements and partner with Engineering to deliver solutions. Collaborate with cross-functional teams to deploy customer-facing AI solutions that streamline communication, create engaging content, and personalize outreach. Define and optimize end-to-end customer experience (CX) flows across AI-powered touchpoints, ensuring interactions are intuitive, cohesive, and aligned with provider and patient needs. Identify friction points, improve user journeys, and drive measurable improvements in engagement, satisfaction, and service efficiency. Partner with Operations to automate workflows, integrate AI into the CRM and support tools, and enable faster, more accurate decision-making. Partner with Compliance and Legal to ensure AI solutions meet regulatory, privacy, and ethical standards. Measurement & Stakeholder Engagement Define and track success metrics that demonstrate efficiency gains, customer impact, and scalability. Communicate program updates, trade-offs, and outcomes to executive stakeholders with clarity and influence. Qualifications 7+ years of product management experience, with 2+ in AI/ML-driven products. Strong knowledge of conversational, generative, agentic, and predictive AI applications. Proven success delivering AI-enabled solutions in healthcare, diagnostics, or other regulated industries. Deep understanding of healthcare workflows across providers, patients, and operations. Exceptional analytical skills, with the ability to tie AI initiatives to measurable outcomes (efficiency, scale, CX impact). Excellent communication and stakeholder management skills, including executive presentations. Bachelor’s degree in computer science, engineering, business, or related field. AI & Digital Fluency Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work. Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients. The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location: Palo Alto, CA Primary Location Base Pay Range: $188,200 - $258,800 Other US Location(s) Base Pay Range: $159,970 - $219,980 If the role is performed in Colorado, the pay range for this job is: $169,380 - $232,920 Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to View email address on click.appcast.io A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952). Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us! Our Work Experience is the combination of everything that's unique about us: our culture, our core values, our company meetings, our commitment to sustainability, our recognition programs, but most importantly, it's our people. Our employees are self-disciplined, hard working, curious, trustworthy, humble, and truthful. They make choices according to what is best for the team, they live for opportunities to collaborate and make a difference, and they make us the #1 Top Workplace in the area.