Senior Director, Market Transformation - Pain

Job Description Job Summary Vertex is seeking a Senior Director, Market Transformation to help position the company as a commercial leader in delivering life-changing medicines to patients through innovative capabilities, cutting-edge solutions, and strategic partnerships. This role will identify emerging market trends, bring external insights into the organization, and translate opportunities into scalable programs that increase awareness for our brands, improve patient access, and support business objectives. The Senior Director will work cross-functionally to shape strategic decisions, accelerate innovation, and strengthen relationships with influential stakeholders across the healthcare ecosystem. This leader will play a critical role in improving patient access to our medicines while supporting sustainable growth across Vertex’s portfolio. Key Responsibilities Monitor the external healthcare, market, and policy landscape to identify trends, risks, and opportunities relevant to Vertex brands and access strategies. Provide actionable market insights that enable cross-functional teams to make informed brand, access, and commercialization decisions. Support key product launches and portfolio optimization efforts by identifying market transformation opportunities that drive sustainable growth. Evaluate and advance new solutions in areas such as AI, digital health, and alternative distribution models (e.g., CDS, telehealth). Design, develop, and activate innovative programs that drive awareness for our brands and improve patient access (e.g., develop business care, scout/select solutions, gain approval of programs). Rigorously evaluate the business value of proposed opportunities and capabilities using defined criteria, prioritizing programs with the most potential. Establish and monitor adoption metrics and key KPIs, providing regular reporting to BU leadership on utilization and value realization. Continuously assess operational efficiencies and innovative approaches that improve execution and patient outcomes. Scale programs that demonstrate measurable impact and are ready for broader implementation across teams and partners. Partner closely with Commercial, Market Access, Medical, Patient Support, Legal, Compliance, and other key functions to ensure alignment and execution. Identify and cultivate relationships with new and influential external stakeholders, organizations, and partners to expand reach and enhance patient impact. Lead with a strategic, patient-centered mindset while ensuring programs align with Vertex goals, standards, and compliance requirements. Act as the primary liaison on BULT for market transformation, translating business needs into clear, prioritized opportunities and owning program execution within the BU. Qualifications Bachelor’s degree required; advanced degree preferred. 12+ years of educational/work experience in biopharmaceuticals, healthcare strategy, commercial innovation, market access, consulting, or a related field. Significant Proven ability to translate external market insights into strategic recommendations and business action. Experience developing and implementing innovative healthcare solutions, partnerships, or patient access programs. Strong understanding of the healthcare ecosystem, including market dynamics, access considerations, and stakeholder engagement. Demonstrated success leading complex, cross-functional initiatives in a highly matrixed environment. Strong executive presence, communication, and influence skills. Ability to identify opportunities early, solve problems creatively, and drive execution with measurable impact. Leadership Competencies: Strategic thinker with strong external orientation; Innovative and solutions-focused; Collaborative and highly effective in cross-functional environments; Results-driven with strong operational discipline; Patient-centered and mission-driven; Skilled at building partnerships and influencing across internal and external stakeholders. Pay Range Pay Range: $232,000 - $348,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io. Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency. Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work. #J-18808-Ljbffr Vertex Pharmaceuticals Inc (US)