Senior Machine Learning Engineer

Senior Machine Learning Engineer

Framingham, MA

At Definitive Healthcare, we're passionate about turning data, analytics, and expertise into meaningful intelligence that helps our customers achieve success and shape the future of healthcare. We empower them to uncover the right markets, opportunities, and people—paving the way for smarter decisions and greater impact.

Headquartered just outside of Boston, Massachusetts, Definitive Healthcare operates across North America, Europe, and India, supporting a growing global client base of more than 2,400 customers since our founding in 2011.

We foster a collaborative, inclusive culture where diverse perspectives drive innovation. Through programs like DefinitiveCares and our employee-led affinity groups we strive to promote connection, education, and inclusion.

We are looking for a Senior Machine Learning Engineer to lead the design and implementation of cutting-edge AI/ML systems that deliver transformative business outcomes. In this role, you will take ownership of end-to-end ML solutions, from architecture and modeling to production and performance optimization.

From architecting end-to-end ML solutions to shaping technical strategy, your work will have a broad and lasting impact on customer experience and operational efficiency. The ideal candidate brings extensive experience in applied machine learning, deep software engineering expertise, and a track record of mentoring teams and delivering production-ready models at scale. This is a high-impact, full-stack ML role that blends research, engineering, and leadership, with the opportunity to shape both the company's technical foundation and product direction.

What You'll Do

ML Systems Development & Deployment

• Lead the design and implementation of scalable, production-grade ML systems in cloud environments with a focus on performance, reliability, and reproducibility.
• Collaborate with product managers and senior stakeholders to define and prioritize ML initiatives aligned with business goals.

Data Pipeline & Feature Engineering

• Oversee the architecture and evolution of data pipelines for multi-terabyte datasets, ensuring efficiency and reliability.
• Guide the development of high-impact features and label sets across diverse domains such as healthcare and consumer analytics

Experimentation & Model Management

• Lead experimentation strategy, including design of A/B tests, advanced validation methods, and lifecycle management using tools like MLflow and Databricks.
• Drive continual model improvement through advanced techniques such as automated retraining, model decay analysis, and bias mitigation. Innovation & Prototyping
• Champion rapid prototyping and proof-of-concept development to evaluate emerging technologies and ML techniques.
• Lead technical explorations into new ML architectures (e.g., foundation models, causal inference, time series deep learning).

Cross-Functional Collaboration

• Serve as a technical leader and trusted advisor, working closely with product, engineering, data, and executive teams to shape end-to-end ML solutions. Code Quality & Documentation
• Set standards for code quality, performance, and documentation, and mentor junior engineers in best practices

What You'll Bring

• Bachelor's or Master's degree in Computer Science, Machine Learning, Data Science, or a related field (or equivalent practical experience).
• 5+ years of industry experience as an ML Engineer, Data Scientist, or Data Engineer, with a focus on deploying and scaling ML systems.
• Deep expertise in Python, SQL, and PySpark for distributed data processing, with proficiency in libraries like scikit-learn, PyTorch, and XGBoost.
• Proven experience designing robust ML pipelines, leveraging tools like MLflow or equivalent.
• Strong command of ML frameworks (e.g., scikit-learn, TensorFlow, XGBoost, PyTorch).
• Hands-on experience deploying models in cloud-based environments (AWS, GCP, Azure, and Databricks).
• Proven ability to manage end-to-end ML lifecycles at scale, including data ingestion, training, evaluation, deployment, and monitoring.
• Excellent communication skills and demonstrated ability to influence cross-functional teams.

Preferred Qualifications

• Experience working with healthcare claims, EHR, or life sciences datasets.
• Advanced degree (M.S. or Ph.D.) in Computer Science, Data Science, or related technical field.
• Strong knowledge of MLOps practices including CI/CD for ML, automated retraining, and model versioning.
• Experience with deep learning architectures for time series forecasting, sequential data, or hierarchical modeling.
• Proficient in designing evaluation protocols and defining performance metrics to rigorously assess model effectiveness and drive data-driven decision-making.
• Comfortable operating in fast-paced, high-ownership environments, and able to prioritize multiple high-impact projects

Compensation and Benefits

The salary range for this position is $112,000 – $210,000 per year, which represents the base pay the company reasonably and in good faith expects to pay for this role. Actual compensation will depend on relevant experience, skills, and qualifications.

This role is also eligible to participate in the company's annual bonus program, subject to individual and company performance.

All employees receive standard benefits, including medical, dental, and vision coverage, unlimited paid time off, and participation in the company's 401(k) plan with employer contribution.

Why We Love Definitive, and Why You Will Too!

• Industry leading products
• Work hard, and have fun doing it
• Incredibly fast growth means limitless opportunity
• Flexible and dynamic culture
• Work alongside some of the most talented and dedicated teammates
• Definitive Cares, our community service group, gives all of us a chance to give back
• Competitive benefits package including great healthcare benefits and a 401(k) match

What Our Employees Are Saying About Us On Glassdoor:

"Great Work atmosphere, great work life balance, excellent company to work for, amazing top notch product, incredible customer service, lots of tools to help you succeed."

-Business Development Manager

"Great team. Amazing growth. Employees are treated very well."

-Research Analyst

"I have waited 36 years to work at a dream job for a dream company and I am so happy to have finally got there."

-Profile Analyst

If you don't fit all of these qualifications, but believe you're still a great fit, feel free to apply and tell us why in your cover letter.

If you are a California, Colorado, New York City or Washington resident and this role is a remote role, you can receive additional information about the compensation and benefits for this role, which we will provide upon request.

Definitive Healthcare is an equal opportunity employer that celebrates diversity and is committed to creating an inclusive workplace with equal opportunity for all applicants and teammates. Our goal is to recruit the most talented people from a diverse candidate pool regardless of race, color, religion, age, gender, gender identity, sexual orientation or any other status. If you're interested in working in a fast growing, exciting working environment – we encourage you to apply!

Privacy Your privacy is important to us. Please review our Candidate Privacy Notice which tells you how we use and process your personal information.

Please note: All communications regarding the hiring process at Definitive Healthcare will come directly from one of our corporate recruiters or coordinators using an @definitivehc.com email address. We do not advertise open roles on Facebook and will never request money transfers or ask candidates to purchase equipment with a promise of reimbursement. If you receive any suspicious communication, please contact View email address on click.appcast.io to verify your status in the application process.