Principal AI Engineer
$206.6k - $284.3kHumana
Become a part of our caring communityEvery large organization is making critical decisions today about how it will leverage AI over the next decade. Few have leaders who can both define that vision and demonstrate its viability through hands-on engineering. This role requires both.We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs) to read medical records, extract structured facts, answer complex questions with citations to source documents, and route difficult cases to human experts. These capabilities support decisions that impact real healthcare outcomes for members.As a Principal AI Applied Engineer, you will define the technical strategy, architectural standards, and long-term vision for AI-enabled products across the organization. You will influence enterprise-wide decisions regarding AI platforms, model strategies, engineering standards, and technology investments while remaining deeply hands-on in prototyping, experimentation, architecture, and software development.This is the highest-level individual contributor role within the AI Applied Engineering organization. Success requires exceptional technical depth, organizational influence, strategic thinking, and the ability to translate emerging AI capabilities into scalable, reliable, and responsible production systems.Why Join UsShape the long-term AI architecture and engineering direction for a large enterprise healthcare organization.Influence how AI-enabled products are designed, built, evaluated, deployed, and governed across multiple teams.Drive strategic decisions involving models, vendors, platforms, infrastructure, and shared capabilities.Prototype and validate emerging technologies before the organization invests at scale.Establish engineering standards and platform capabilities that will influence the business for years to come.Solve complex challenges involving trust, explainability, compliance, reliability, and operational excellence in AI systems.Work on systems that process healthcare information at significant scale and directly support member outcomes.Remain hands-on with architecture, software development, experimentation, and technical problem solving.Key ResponsibilitiesDefine and drive the long-term technical strategy, reference architecture, and technology roadmap for AI-enabled products and platforms.Establish architectural patterns and best practices for retrieval systems, LLM orchestration, agentic workflows, human-in-the-loop processes, evaluation frameworks, and AI governance.Lead organization-wide technical decision-making regarding model strategy, vendor selection, platform investments, build-versus-buy decisions, and shared infrastructure capabilities.Design and champion scalable architectures that balance reliability, performance, security, compliance, maintainability, and cost efficiency.Establish engineering standards for evaluation, observability, model lifecycle management, responsible AI practices, and operational excellence.Build prototypes, proofs of concept, and reference implementations that de-risk emerging technologies and strategic platform investments.Lead cross-functional architecture reviews and provide technical guidance across multiple engineering teams.Mentor Lead Engineers, Senior Engineers, and emerging technical leaders through architecture reviews, design feedback, coaching, and technical sponsorship.Develop and communicate technical roadmaps aligned with business strategy and organizational objectives.Partner with executive leadership to translate business priorities into technical strategies and communicate technical opportunities, risks, and tradeoffs.Represent engineering in strategic vendor evaluations, compliance discussions, governance reviews, and enterprise planning initiatives.Drive adoption of common platforms, standards, and engineering practices across teams.Ensure AI systems are designed and operated in accordance with privacy, security, compliance, governance, and auditability requirements.Use your skills to make an impact Required QualificationsBachelor's degree in Computer Science, Engineering, or a related technical field, or equivalent practical experience.12+ years of software engineering experience, including extensive experience designing and operating large-scale distributed systems.Proven track record of designing, delivering, and operating production AI-enabled platforms or products at enterprise scale.Deep expertise in large language model technologies, AI platform design, retrieval-augmented generation (RAG), agentic systems, orchestration frameworks, evaluation methodologies, and AI operations.Extensive experience designing cloud-native architectures and highly scalable, resilient systems.Demonstrated ability to define technical direction that influenced teams, organizations, or product portfolios beyond direct reporting relationships.Experience establishing engineering standards, architectural frameworks, or technical platforms that have been successfully adopted across multiple teams.Strong understanding of AI operational challenges, including model reliability, latency, cost optimization, governance, observability, and risk management.Demonstrated success influencing executive stakeholders and driving organizational decisions through technical leadership and evidence-based recommendations.Expert-level proficiency in Python and/or TypeScript/JavaScript.Ability to prototype, debug, review, and contribute code across multiple layers of the technology stack.Preferred QualificationsExperience leading AI platform strategy across multiple business units or product organizations.Experience developing enterprise standards for AI evaluation, testing, observability, governance, and responsible AI practices.Expertise evaluating and managing AI vendor ecosystems across multiple model providers and platform technologies.Experience building shared AI infrastructure and platform capabilities consumed by multiple engineering teams.Experience with agentic architectures, Model Context Protocol (MCP), workflow orchestration, autonomous systems, and emerging AI frameworks.Experience operating AI systems at significant scale while managing performance, reliability, and cost tradeoffs.Experience working in regulated industries such as healthcare, financial services, life sciences, or government.Deep understanding of privacy, security, compliance, governance, and risk management requirements in highly regulated environments.Experience driving adoption of AI-assisted software development practices across engineering organizations.Experience advising executive leadership on emerging technologies, platform strategy, and enterprise architecture decisions.Exceptional communication, leadership, collaboration, and strategic problem-solving skills.Leadership ExpectationsServe as the highest-level technical authority within the AI Applied Engineering organization.Influence organizational outcomes through technical excellence, credibility, and demonstrated results rather than formal authority.Balance innovation with operational discipline and long-term sustainability.Establish scalable technical standards that enable teams to move faster while maintaining quality and reliability.Drive alignment across engineering, product, business, clinical, compliance, and executive stakeholders.Build organizational capability by mentoring and developing the next generation of technical leaders.Foster a culture of engineering rigor, continuous learning, accountability, and responsible AI development.Success in This RoleSuccessful candidates are respected technical leaders who combine strategic thinking with hands-on execution. They influence organizations through technical expertise, data-driven decision-making, and working solutions rather than formal authority alone.You are energized by difficult, long-horizon problems and are comfortable making high-impact decisions that affect multiple teams and products. You view AI architecture, governance, reliability, and responsible deployment as critical engineering disciplines, not afterthoughts.Most importantly, you remain a builder. Your strategies are informed by real experience developing, testing, and operating production systems, and your credibility comes from your continued ability to solve hard technical problems through architecture, experimentation, and code.Technology StackTypeScriptReact / Next.jsPythonPostgreSQLGemini on Vertex AIOCR and Document AI technologiesDockerKubernetesModern CI/CD platforms and toolingAdditional InformationThis role operates in a highly regulated environment where responsible handling of sensitive and protected information is fundamental. Success requires a commitment to building secure, compliant, auditable, and trustworthy AI systems that meet the highest standards for privacy, reliability, and quality.Work Style: This position follows a hybrid work schedule, requiring employees to work three days per week in the office and the remaining days remotely. Qualified candidates must currently reside within, or be willing to relocate to, a commutable distance from one of the talent markets.#enterpriseAIScheduled Weekly Hours40Pay RangeThe compensation range below reflects a good faith estimate of starting base pay for full time (40 hours per week) employment at the time of posting. The pay range may be higher or lower based on geographic location and individual pay will vary based on demonstrated job related skills, knowledge, experience, education, certifications, etc.$206,600 - $284,300 per yearThis job is eligible for a bonus incentive plan. This incentive opportunity is based upon company and/or individual performance.Description of BenefitsHumana, Inc. and its affiliated subsidiaries (collectively, “Humana”) offers competitive benefits that support whole-person well-being. Associate benefits are designed to encourage personal wellness and smart healthcare decisions for you and your family while also knowing your life extends outside of work. Among our benefits, Humana provides medical, dental and vision benefits, 401(k) retirement savings plan, time off (including paid time off, company and personal holidays, paid parental and caregiver leave), short-term and long-term disability, life insurance and many other opportunities.About UsAbout Humana: Humana Inc. (NYSE: HUM) is a leading U.S. healthcare company. Through our Humana insurance services and our CenterWell healthcare services, we make it easier for the millions of people we serve to achieve their best health – delivering the care and service they need, when they need it. These efforts are leading to a better quality of life for people with Medicare and Medicaid, families, individuals, military service personnel, and communities at large. Learn more about what we offer at Humana.com and at CenterWell.com.Equal Opportunity EmployerIt is the policy of Humana not to discriminate against any employee or applicant for employment because of race, color, religion, sex, sexual orientation, gender identity, national origin, age, marital status, genetic information, disability or protected veteran status. It is also the policy of Humana to take affirmative action, in compliance with Section 503 of the Rehabilitation Act and VEVRAA, to employ and to advance in employment individuals with disability or protected veteran status, and to base all employment decisions only on valid job requirements. This policy shall apply to all employment actions, including but not limited to recruitment, hiring, upgrading, promotion, transfer, demotion, layoff, recall, termination, rates of pay or other forms of compensation and selection for training, including apprenticeship, at all levels of employment.SummaryLocation: New York, NY; Louisville, KY; Dallas, TXType: Full time
- ...organization of forward thinkers looking to add industry experts to our growing team. About the Role We are seeking a Principal AI Engineer to lead the design, development, and deployment of AI-powered systems across the company. This role spans customer-facing AI...Suggested
$180k - $200k
...Join our global team and see what makes Mitratech a truly exceptional place to work! Role Overview We are looking for a Principal AI Engineer to guide a distributed team of developers in building modern, scalable, and AI-integrated software solutions. As a technical...SuggestedWork at officeRemote work$206.6k - $284.3k
Humana is hiring a Principal AI Applied Engineer to define long-term AI technical strategy and architecture for enterprise healthcare AI-enabled products, while also contributing hands-on through prototyping, experimentation, and software development. This role shapes model...SuggestedTemporary workWork at officeRemote workRelocation3 days per week$189.4k - $260.5k
...Become a part of our caring community We are seeking an accomplished Director of AI Engineering to lead the strategy, architecture, and delivery of enterprise-scale agentic AI capabilities within Humana's AI platform. This leader will drive the development of foundational...SuggestedFull timeTemporary workApprenticeshipCasual workWork at officeWork from home- ...Title: I Engineer Location: Louisville, KY Duration: 6 months Job description: Must to have Agentic AI Full stack with RAG, MCP, MultiAgent orchestration, end to end deployment experience, LanEligible to workhain. Strong Python programming,...Suggested
- ...Job Title: AI Engineer - Agentic AI / Generative AI Location: Louisville, KY Duration: 6 months Experience Required: 8-10 years Primary Focus: Agentic AI, RAG, MCP, Multi-Agent Orchestration, Python, LangChain, LangSmith, and Graph Databases Keyword: AI and Automation...
$200k - $225k
...Senior AI Engineer - Agentic Systems Remote (NYC HQ) $200,000-225,000 Base Salary + Equity THE COMPANY Harnham is partnering with a high-growth AI-native technology company building a next-generation platform for the advertising and marketing industry. The business is...Work at officeLocal areaRemote work- ...We're looking for a Founding AI Engineer to join us at ProgentAI. We're building an autonomous Supply Chain AI platform starting with sourcing and procurement in regulated industries, and we already have a large enterprise customer working with us on our first proof...
- ...Entry-Level Generative AI Engineer / AI Engineer We are looking for a motivated *Entry-Level Generative AI Engineer / AI Engineer* to join our team. You will work alongside experienced engineers to build, test, and improve AI-powered applications using Python, large...Full timeInternship
$141.1k - $194k
Become a part of our caring communityMost AI engineering jobs are a thin wrapper around a model API. This role is different.We build the platform that transforms millions of clinical documents into trusted, actionable data. Our systems use large language models (LLMs)...Full timeTemporary workApprenticeshipWork at officeRemote workRelocation3 days per week- ...two-way texting, digital forms, automated workflows, and OhMD AI, our voice and text agent. OhMD AI answers on the first ring, handles... ..., on a real call. You'll build that. This is a hands-on engineering role: you'll design, configure, test, and debug the agents our...Agency workFreelanceLive inRemote work
$170.8k - $234.8k
...Lead AI Applied Engineer role at Humana providing technical leadership for production AI systems using LLMs in a regulated healthcare environment. Responsibilities Lead architecture for production AI systems where LLMs are foundational to the product experience Own key...Temporary workWork at officeRemote workRelocation3 days per week- ...Lead AI Engineer, Internal Tooling Location: Remote, Nationwide Our client is seeking a senior, hands-on engineer to shape a new generation of intelligent internal systems. This is an opportunity to work across the business, uncover high-value operational challenges...Remote work
- ...change: graded suites, regression gates, human review. - Context engineering. Prompts, retrieval and memory as one budget; you know what the... ...an agent product. HOW WE WORK Everyone runs several AI coding agents using our custom dev tooling within a proven...Remote work
- ...Lead Applied AI Engineer We are seeking an accomplished Lead Applied AI Engineer to architect and deliver advanced AI systems that seamlessly integrate Generative AI capabilities, AI agents, and modern enterprise platforms. This role is responsible for designing,...
- ...About Synthreo Synthreo is the AI layer for managed service providers. We give MSPs everything they need to run, brand, and bill an AI practice without hiring ML engineers: Threo, the white-labeled AI workspace their clients log into, and Pylon, where agents are...Full timeRemote work
$40 - $52 per hour
...We are seeking a Senior GCP ML/AI Engineer to design, build, deploy, and operationalize production AI and machine learning solutions using Google Cloud technologies. The role is focused on hands-on engineering with Google's ML/AI ecosystem, including Gemini and related...Contract workRemote work- ...Sierra Space is seeking a Sr Test Engineer to lead advanced testing and validation of aerospace systems and components for satellite and spacecraft programs. You will mentor early career engineers and act as the prime technical contact on major programs. The role requires...
$150k - $200k
...benefits, and initiatives that are integrated into the fabric of how we work every day. To learn more, please see . The AI Automation Engineer - Finance & Accounting applies AI to finance operations at Cengage to reduce cost, increase accuracy, and eliminate manual...Full timeLive inLocal areaWorldwide$180k - $260k
...Help promising AI experiments become dependable products. Irys is hiring an AI Infrastructure / Product Engineer to build the evaluations, services, and product features that bring applied AI into legal work. Full-time · Remote · United States only Annual base...Full timeRemote work- ...Job Title AI Software Engineer Intern Date posted 14-Oct-2026 Job ID 137214 City / Township / Village POUGHKEEPSIE, DURHAM, San Jose, New York State / Province New York, North Carolina, California Country United States Work arrangement Hybrid...Contract workFixed term contractInternshipShift work
- ...TALENT Software Services in Louisville, KY is seeking an AI Engineer to lead agentic AI initiatives, building full‑stack, production‑ready GenAI solutions with RAG and multi‑agent orchestration capabilities. The role focuses on deploying AI applications using Python, LangChain...Contract work
$124k - $280k
...At PwC, our people in data and analytics engineering focus on leveraging advanced technologies and techniques to design and develop robust... ...learning at PwC will focus on developing and implementing advanced AI and ML solutions to drive innovation and enhance business...H1b$18 - $50 per hour
...university graduation and completion of the program Position Overview: Siemens Digital Industries Software is seeking an AI & Engineering Data Intern to support emerging Artificial Intelligence and Digital Thread initiatives within the Capital PreSales...Remote jobHourly payFull timeInternshipLocal area$155k - $410k
...ApplicableSpecialismApplication / Solution ArchitectureManagement LevelDirectorJob Description & SummaryThe OpportunityAs a Director, AWS AI Application Engineering you will lead the design, development, testing, and modernization of AWS-native applications that support client needs...Full timeH1b- ...in Colorado, Utah, or Florida** Our client seeks a hands-on Principal Engineer to shape the future of its customer onboarding platform while... ...with Engineering, Product, Customer Success, and Sales to embed AI capabilities across the platform and solve complex customer...Contract workRemote work
$173.75k - $238.9k
...mission‑ready throughout space. We are mission‑driven, and together, we are an extraordinary team. About the Role The Principal Project Engineer role involves leading and executing large-scale technical projects, ensuring the successful integration of engineering...Contract workWork experience placementWork at office- ...The Principal Advanced Manufacturing Engineer (AME) is a member of a product line AME team responsible for providing manufacturing support New Product Introduction... ...environments as well as Openness to leveraging AI-assisted tools and technologies to support technical documentation...Full time
- ...This Global Specialty Products technology team program engineer position is an integral role in the development and implementation... ...every way is paramount to position success. Position Principal Design Engineer Location USA, Louisville, KY How You...Work at officeFlexible hours
$123.8k - $188.6k
...big, embrace challenges and explore new ideas to lead the way for the travel industry.ARC is looking for a talent Manager, DevOps Engineering to join our team! In this role, you will provide thought leadership, strategic planning, operational excellence, and a high level...Work at officeWork from homeFlexible hours
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal AI Engineer. Be the first to apply!
- engineering director Louisville, KY
- hotel chief engineer Louisville, KY
- senior civil engineer project manager Louisville, KY
- principal engineer Louisville, KY
- principal developer Louisville, KY
- chief engineer Louisville, KY
- general engineer Louisville, KY
- data center chief engineer Louisville, KY
- director software engineering Louisville, KY
- ai developer Louisville, KY





