Research Associate 1, MS

Research Associate IWorking at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community, eligible for opportunities through the New Haven Hiring Initiative, or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale!Job Description:Research Associate I will perform laboratory experiments and data analysis supporting studies of bone physiology using cellular, molecular, histological, flow cytometry, and animal-based techniques.Responsibilities include animal husbandry and handling, FACS experimentation and analysis, tissue processing and staining, and analysis of large-scale experimental datasets.Key Responsibilities:Design and conduct experiments using transgenic and wild-type mouse models of skeletal biology and disease.Perform animal procedures, tissue harvest, and phenotypic characterization in accordance with IACUC protocols.Utilize molecular and cellular techniques including PCR, qPCR, RNA and protein analyses, histology, immunohistochemistry, RNA in situ hybridization, cell culture, and microscopy.Analyze bone structure and function using imaging modalities such as microCT and histomorphometry.Interpret experimental data using appropriate statistical methods and prepare figures for publication.Maintain detailed laboratory notebooks and ensure rigorous data management and reproducibility.Prepare manuscripts, abstracts, grant applications, and presentations for scientific meetings.Supervise and mentor graduate students, technicians, and trainees in laboratory techniques and experimental design.Manage mouse colonies, laboratory inventories, reagent procurement, and shared equipment.Required Skills and Abilities:Flow Cytometry (FACS): Demonstrated ability to perform flow cytometry experiments, including sample preparation, panel development, instrument operation, data acquisition, and analysis.Animal Husbandry and Handling: Ability to safely and appropriately handle and maintain laboratory animals, including routine husbandry, genotyping, and preparation for experimental procedures in accordance with institutional guidelines.Histology and Tissue Processing: Experience with tissue collection, fixation, processing, sectioning, and histological staining techniques for evaluation of bone and other tissues.Large-Scale Data Analysis: Ability to organize, analyze, and interpret large datasets generated from experimental studies, with proficiency in relevant computational and statistical tools.Wet-Lab Experimental Skills: Strong technical skills in molecular and cellular biology techniques, with the ability to independently perform experiments, troubleshoot protocols, maintain accurate records, and work effectively in a collaborative research environment.Preferred Skills and Abilities:IACUC/Animal Research Training – Completion of institutional training in the ethical use, handling, restraint, and care of laboratory animals, including species-specific training for mice and/or rats.CITI Program Training – Completion of applicable CITI Program courses in animal care and use, biosafety, and responsible conduct of research.Laboratory Safety Training – Required institutional training in chemical hygiene, biosafety, bloodborne pathogens, hazardous materials, and laboratory safety.Flow Cytometry/FACS Training – Documented training or demonstrated competency in flow cytometer operation, cell sorting, instrument maintenance, and FACS data analysis.Animal Handling/Surgical Training – Completion of institutionally approved training for animal handling and, where applicable, anesthesia, injections, tissue collection, and other experimental procedures. A veterinary or professional animal-care license is generally not required for a Research Associate I unless the position specifically involves regulated veterinary duties.Principal Responsibilities:Recommends the design and implementation of procedures and protocols under the direction of a higher-level authority.Investigate, analyze, and reach preliminary scientific conclusions related to research planning.Ensures data results are compiled, analyzed, and presented properly.Analyzes, develops and interprets scientific results. Maintains clear documentation of results. Prepares scientific reports and papers for research proposals and published reports.Performs independent research and laboratory techniques and participates in experimental research planning.Interacts with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory.Interacts with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments.May perform other duties as assigned.Required Education and Experience: Master's Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.Compensation Grade: Research Associate 1 MS (22)Salary Range: $61,500.00 - $91,875.00Yale University is a tobacco-free campus.