Senior Director, US Compliance

Revolution Medicines is a late‑stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D‑selective inhibitor; and RMC-5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity The Sr. Director, US Compliance will serve as the lead compliance business partner in support of the company’s planned US commercialization activities for non‑small cell lung cancer (NSCLC). The Sr. Director will partner with a range of business functions, serve as a trusted resource for compliance guidance, and ensure launch teams successfully navigate the compliance landscape. This role requires a firm understanding of pharmaceutical best practices and industry requirements, as well as the passion and ability to build relationships with a diverse set of teams all working to revolutionize treatments for patients. This position will report to the VP, US Compliance. This position will be based out of Redwood City, CA on a hybrid basis. Essential Duties and Responsibilities Serve as the strategic compliance advisor to Commercial, Medical Affairs, Market Access, Patient Services, and other field‑facing functions by proactively identifying compliance risks, enabling compliant business solutions, and embedding compliance into key business decisions throughout commercialization and product launch. Lead ongoing compliance risk assessments for field‑facing activities in the NSCLC space, identify emerging risks, and develop practical mitigation strategies in partnership with business leaders and others in Compliance. Represent Compliance on commercialization committees, launch teams and workstreams, and other strategic and tactical decision‑making forums, ensuring compliance considerations are incorporated into strategic business decisions. Serve as lead compliance reviewer and advisor on NSCLC initiatives, ensuring timely, practical, and risk‑based guidance is incorporated into business activities. Lead the design, development, and delivery of engaging, risk‑based compliance training to NSCLC business teams, ensuring compliance risks are appropriately mitigated while fostering a culture of ethics and compliance. Partner with others in Compliance and business stakeholders to develop and continuously improve compliance policies, processes, and other governance controls. Develop, manage, and conduct monitoring and auditing activities to identify and mitigate compliance risks. Champion a culture of ethics, integrity, and accountability by promoting open communication, encouraging appropriate escalation of concerns, and reinforcing ethical decision‑making. Serve as strategic advisor in continuously improving the Compliance program by proposing enhancements, monitoring industry trends and best practices, and bringing the field perspective to discussions. When appropriate given the business growth, build a team of compliance professionals to support the growing NSCLC commercialization field activities. Partner closely with the Healthcare Law team to ensure consistency between legal interpretation and compliance operations. Additional Responsibilities and Role Evolution The responsibilities outlined in this job description are intended to describe the general nature and level of work performed by the individual in this role and are not intended to be an exhaustive list of all duties, responsibilities, or qualifications. The Sr. Director, US Compliance will be expected to take on additional assignments, projects, and responsibilities as needed to support the Compliance team and broader business objectives. Responsibilities may change, expand, or shift over time based on organizational priorities, business growth, process improvements, technology implementations, and evolving legal or regulatory requirements. The successful candidate will demonstrate flexibility, adaptability, and a willingness to contribute beyond the core responsibilities of the position, partnering collaboratively across functions to support the continued success and growth of the company. Required Skills, Experience and Education Bachelor’s degree. 10+ years of healthcare compliance experience in pharmaceuticals or biotechnology; in‑house compliance experience strongly preferred. In‑depth understanding of US healthcare laws and guidance, including the OIG guidelines, PhRMA Code, US Sunshine Law, Anti‑Kickback Statute, False Claims Act, FDA promotional regulations, and the FCPA. Experience as a compliance business partner with familiarity with the compliance risks associated with relevant business activities. Significant experience supporting pre‑commercial pharma or biotech companies through launch planning and commercial product launch. Demonstrated ability to build strong partnerships and collaborate with internal and external partners at all levels of the organization. Strategic and pragmatic compliance mindset with strong business acumen. High ethical standards and sound judgment, and committed to fostering a culture of integrity, transparency, and continuous improvement. Excellent leadership, communication, analytical, and problem‑solving skills, with the ability to work collaboratively with legal, scientific, and business functions. Demonstrated experience leading, developing, and mentoring compliance professionals, or successfully leading through influence in a matrixed organization. Experience leveraging data, insights, and compliance metrics to identify trends and prioritize risk mitigation activities. Strong presentation, organizational, and project management skills, capable of handling multiple high‑priority projects simultaneously. Team‑oriented approach to work, and ability to lead through influence in a dynamic environment. Ability to travel as required (approximately 25%). #LI-TS1 #LI-Hybrid The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. Base Pay Salary Range

$244,000 — $305,000 USD

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