Scientist - Functional Proteomics

Scientist – Functional ProteomicsLocation: Seattle, WACompensation: $115,000–$150,000 annual base salaryEmployment Type: Direct HireWork Arrangement: Primarily onsiteYoh is proactively seeking a Scientist – Functional Proteomics for an anticipated opportunity with a biotechnology company in Seattle, WA.We are looking for a hands-on scientist with expertise in mass spectrometry-based proteomics who can design rigorous quantitative experiments and translate complex proteomic data into meaningful biological insights. This position will support drug-discovery research involving target identification and validation, compound characterization, and mechanism-of-action studies.The ideal candidate combines strong experimental proteomics capabilities with a deep understanding of protein biology and the ability to collaborate across experimental biology, computational science, and drug-discovery teams.What You'll DoDesign and execute quantitative and functional proteomics experiments supporting target discovery, target validation, compound profiling, and mechanism-of-action research.Develop and optimize protein extraction, digestion, enrichment, fractionation, and sample-preparation workflows for mass spectrometry-based studies.Design studies evaluating protein abundance, activity, binding, localization, and responses to compound treatment.Establish appropriate experimental controls, biological and technical replicates, normalization strategies, and quantitative approaches.Develop proteomic strategies for challenging protein classes, including transcription factors, chromatin-associated proteins, and other regulatory proteins.Perform mammalian cell culture and cellular compound-treatment experiments as needed.Generate, analyze, and interpret quantitative proteomics datasets in collaboration with computational scientists.Integrate proteomic findings with genomic, transcriptomic, cellular, and pharmacological datasets to develop biological conclusions.Troubleshoot experimental workflows and improve sensitivity, reproducibility, robustness, and throughput.Support the development of automated and high-throughput proteomics workflows.Present experimental findings, scientific interpretations, and recommendations to cross-functional project teams.Contribute to scientific strategy, technical documentation, publications, and presentations.What We're Looking ForPh.D. in proteomics, biochemistry, molecular biology, chemical biology, analytical chemistry, systems biology, or a related scientific discipline preferred.Hands-on experience with mass spectrometry-based proteomics.Strong understanding of quantitative proteomics experimental design, including sample preparation, controls, replicates, and normalization.Experience generating, processing, and/or interpreting quantitative proteomics datasets.Strong foundation in protein biology and hypothesis-driven experimental science.Demonstrated ability to translate complex datasets into meaningful biological conclusions.Ability to independently troubleshoot experimental workflows and make scientifically sound decisions.Strong communication skills and experience collaborating across multidisciplinary scientific teams.Highly Relevant ExperienceExperience in one or more of the following areas is strongly preferred:Functional proteomics or chemoproteomicsCompound-target identification or target-engagement studiesTarget discovery, target validation, or mechanism-of-action researchThermal proteome profiling or other protein-stability approachesAffinity-based or enrichment-based proteomic methodsDIA, label-free, isotopic, or multiplexed quantitative proteomicsNuclear, chromatin, or transcription-factor proteomicsMammalian cell culture and compound-treatment studiesDrug discovery or pharmacologyAutomated or high-throughput proteomics workflowsProteomics analysis tools such as DIA-NN, Spectronaut, Skyline, FragPipe, MaxQuant, or similar platformsPython and/or RAdditional InformationThis position is anticipated to be primarily onsite in Seattle, WA and will work across experimental biology, analytical science, and computational disciplines. This is an anticipated upcoming hiring need, and Yoh is currently building a pipeline of qualified scientists for consideration as the opportunity progresses.#IND-SPGEstimated Min Rate: $115000.00Estimated Max Rate: $150000.00What’s In It for You?We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)Health Savings Account (HSA) (for employees working 20+ hours per week)Life & Disability Insurance (for employees working 20+ hours per week)MetLife Voluntary BenefitsEmployee Assistance Program (EAP)401K Retirement Savings PlanDirect Deposit & weekly epayrollReferral Bonus ProgramsCertification and training opportunitiesNote: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.Visit to contact us if you are an individual with a disability and require accommodation in the application process.For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. To learn more about Yoh’s privacy practices, please see our Candidate Privacy Notice: Safe During Your Job SearchFraudulent recruiting communications have become increasingly common. Emails from Yoh recruiters will only come from an @yoh.com email address. Yoh will never ask candidates to pay fees, purchase equipment, send gift cards, or transfer funds as part of the recruiting or hiring process. If you receive a communication that appears suspicious or requests payment, contact Yoh directly before responding or sharing personal information.Reference: BH-400241