Scientist - LC-MS/MS Bioanalytical

Join Amgen's mission of serving patients. As a member of the Amgen team, you will help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines. Scientist LC‑MS/MS Bioanalytical In this vital role you will independently support the design, development, validation, and implementation of robust quantitative LC‑MS/MS bioanalytical methods and experiments for small molecules and perform bioanalysis for discovery, GLP preclinical and regulated clinical studies. The position is lab‑based, and additional responsibilities will include critically reviewing and interpreting scientific data and results, report generation, project management, communication of results, data presentations, supporting automation efforts, and keeping current with technology development. The role will involve multidisciplinary collaborations with scientists across research and development at Amgen and may include contribution to key/critical teams and participation in national scientific meetings. This position is also responsible for providing scientific results that may support the generation of publications, patents or regulatory submissions. Familiarity with peptide and protein quantitation by hybrid LC‑MS/MS methodology and affinity capture techniques is a plus. Key Responsibilities Develop and implement LC‑MS/MS bioanalytical methods with quick turnaround times. Conduct small molecule bioanalysis of parent and metabolites in non‑clinical and clinical samples from various matrices (plasma, urine, CSF, tissues). Perform biological sample extraction using protein precipitation, SPE, and LLE. Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems. Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines. Author study reports, standard operating procedures, analytical methods, memos, scientific publications, and other regulatory compliant documents. Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings. Comply with safety guidelines and site‑specific procedures which include but are not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures. Perform general laboratory housekeeping activities and operational support as needed. What We Expect Of You We are all different, yet we use our unique contributions to serve patients. The Scientist we seek is a researcher with the following qualifications. Basic Qualifications Doctorate degree (PhD), PharmD, MD (and relevant post‑doc where applicable), or Masters degree with 3 years of LC‑MS/MS Bioanalytical experience, or Bachelors degree with 5 years of LC‑MS/MS Bioanalytical experience. Preferred Qualifications Prior experience in pharma/biotech strongly desired. Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms. Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, tissues, urine, cerebrospinal fluid) employing diverse sample preparation techniques (e.g., SPE, LLE) to support analysis of small molecules and metabolites by LC‑MS/MS. Experience with an array of analytical equipment and technologies that can accelerate bioanalysis including automation and/or micro‑sampling. Prior GLP and GCP experience. Prior experience in bioanalytical (regulated) assay execution and method transfer to external contract laboratories. Understanding of pharmacokinetic and toxicokinetic principles and analysis. Must be willing to work in a fast‑paced, multi‑project environment with high workload demands, and consistently deliver high‑quality results within established timelines. Demonstrated ability to efficiently resolve scientific challenges, prioritize and effectively manage multiple projects. Excellent scientific problem‑solving skills. Excellent project and time‑management abilities. Ability to work collaboratively with internal and external stakeholders. Supervisory and mentoring experience in a lab‑based setting. Benefits and Compensation The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications. A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan. Stock‑based long‑term incentives. Award‑winning time‑off plans. Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Equal Opportunity Employer Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. #J-18808-Ljbffr BioSpace