Senior Director, US New Product Planning

Job Description General Summary: We are seeking a Senior Director, US New Product Planning, to help shape the future of our pipeline and build the foundation for successful US launches. This is a highly visible leadership role for a strategic, commercially minded, and pragmatic leader who thrives at the intersection of asset strategy, US market planning, and enterprise capability building. This role is ideal for someone who has worked in both the US business and on global teams, and who understands what it takes to succeed in the US market across functions—not just within a single discipline. The individual will represent the US perspective for early pipeline assets, including assets approximately 3 to 4 years from launch, and help ensure that strategic decisions made today translate into successful launches tomorrow. Importantly, this role offers the opportunity to help build a new Business Unit for the organization. As the pipeline advances, this leader will help define the commercial foundation, capability needs, operating model, and resourcing approach required to establish a successful future US business.

Key Responsibilities

• Represent the US commercial perspective on global asset teams for early pipeline assets, especially those approximately 3 to 4 years from launch
• Lead development of US commercial strategy in partnership with global commercial, medical, market access, HEOR, analytics, operations, and finance
• Translate asset strategy into a clear US launch blueprint, including:
  • market development priorities
  • launch scenarios and key assumptions
  • capability requirements
  • organization design implications
  • field force and non-personal promotion considerations
  • budget and investment needs
• Identify and frame key strategic choices related to:
  • positioning
  • patient finding and market development
  • access and reimbursement readiness
  • evidence generation priorities
  • customer engagement model
  • patient services and support strategy
• Develop milestone-based and scenario-based plans that prepare the organization for launch well before traditional pre‑launch planning begins
• Partner with cross-functional leaders to define the capabilities, talent, processes, and infrastructure needed for launch success
• Assess organizational readiness and recommend how to build, buy, or borrow required capabilities
• Provide strategic input on US commercialization models, including implications for specialty, institution‑based, and buy‑and‑bill markets
• Support governance and executive decision‑making with clear recommendations, tradeoffs, and risk assessments
• Help ensure a smooth transition from early planning into launch readiness and in‑market execution
• Help define the strategic and organizational foundations of a new Business Unit

Required Experience

• Significant experience in biotech or pharmaceutical commercial strategy, new product planning, marketing, launch strategy, or related roles
• Meaningful experience in both: US commercial/business roles global or enterprise asset/team roles
• Demonstrated success in new product planning, pre‑launch strategy, or launch planning
• Deep experience in neurology and/or rare disease
• Strong understanding of US commercialization in complex specialty markets, including buy‑and‑bill dynamics and related access, site‑of‑care, and reimbursement considerations
• Experience building or shaping resourcing plans, operating models, and capability roadmaps
• Proven ability to influence senior stakeholders and lead through a matrixed environment
• Strong track record of cross‑functional collaboration across commercial, medical, market access, analytics, operations, finance, and patient services

Preferred Experience

• Experience in US commercial planning, brand leadership, or business leadership
• Experience serving on a global asset team or in a global commercial strategy role
• Experience in specialty markets and complex launch environments
• Experience supporting assets from development through launch readiness
• Experience with provider‑administered therapies and commercialization models involving buy‑and‑bill

Critical Capabilities

• Enterprise thinking — sees beyond function and understands the full set of enablers required for US launch success
• US market insight — understands customer, access, evidence, reimbursement, and operational realities in the US
• Cross‑functional integration — connects perspectives across teams to create practical, aligned plans
• Launch planning excellence — translates strategic choices into launch milestones, readiness plans, and execution requirements
• Organizational and capability planning — defines what talent, structure, and capabilities will be needed over time
• Executive communication — distills complexity into clear, compelling recommendations
• Pragmatic decision‑making — operates effectively under uncertainty and turns ambiguity into action

Why This Role Stands Out

This is a unique opportunity to influence some of the most important decisions in the pipeline—before launch planning is fully formed and while strategic choices can still shape outcomes. You will have the chance to: shape the future of the US business influence asset strategy at an early stage work across US and global leadership define how the organization prepares for future launches help build the foundation of a new Business Unit, including strategic priorities, capabilities, and organizational readiness bring both strategic rigor and practical judgment to high‑impact decisions

Success in This Role Looks Like

• The US perspective is incorporated early and meaningfully into asset strategy
• Strategic choices are translated into actionable US launch and capability plans
• Leadership has clear visibility into risks, tradeoffs, and investment needs
• The organization is better prepared for launch—earlier, more thoughtfully, and with greater alignment
• Cross‑functional teams are aligned around a practical path to US success
• The role contributes meaningfully to the build‑out of a new Business Unit

Pay Range:

$228,000 - $342,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On‑Site Eligible

1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on‑site with ad hoc flexibility.

Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On‑Site: work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life‑shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion‑dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha‑1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.