Columbia University - Yang Lab

630 West 168th Street, New York, NY 10032, USA

Postdoctoral Position - Cancer Cell Cycle Biology and Therapeutic Resistance

The Yang Lab at Columbia University Irving Medical Center, part of the Herbert Irving Comprehensive Cancer Center, is recruiting a postdoctoral fellow.

We study how cancer cells regulate cell cycle entry, and how they adapt to escape targeted therapies without acquiring new mutations. Our approach combines live single-cell imaging with fluorescent biosensors, CRISPR functional genomics, and patient-derived organoid and in vivo tumor models. Active projects span breast cancer, melanoma, and lung cancer, and include work on Rb and E2F regulation, CDK4/6 inhibitor resistance, and rewiring of RAS and MAPK signaling under therapy.

We are looking for a motivated scientist with:

• A PhD or expected completion soon, in cell biology, cancer biology, molecular biology, or a related field
• At least one first-author publication
• A genuine interest in mechanistic cancer research

Experience with quantitative imaging, CRISPR functional genomics, or mammalian cancer models is an advantage. Candidates with a strong foundation in cell cycle regulation in any model system are also welcome, including those without prior cancer-specific experience.

We offer a collaborative environment with access to outstanding imaging and genomics core facilities, close ties to translational cancer research at Columbia, and support for fellowship applications.

• Subsidized housing is available to postdocs through Columbia Residential.

More on our research at heewonyanglab.com