Scientist II, Bioanalytical and Biomarker Development

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.Description: Wave Life Sciences is seeking a highly motivated individual to join the Preclinical and Clinical Development Sciences team in Lexington, Massachusetts. The Scientist II, Bioanalytical and Biomarker Development will support the clinical stage program teams aiming to deliver bioanalytical data and reports, which directly support toxicology, PK/PD studies in preclinical settings through clinical studies. In addition, this individual will support target engagement, PK/PD and tolerability studies in preclinical settings.Experience: B.S. / M.S. and 8 or more years relevant experience in industryResponsibilities: May include some or all of the following:Perform method development and qualifications for oligos in biological matrix using LC-MS/MS, MSD and/or ELISA based assaysPerform sample analysis according to established method protocols in different biological matrix, e.g. blood, plasma, tissue etc.Involved in planning experimental design and execution of all aspects of bioanalysis, efficient assay development to support investigative Tox and PK studiesTransfer methods to CROs and manage their workAdept at preparation of clear and accurate reports for internal and external projectsPrepare clearly articulated experimental reports and data presentationsKey Skills: Hands on experience across bioanalytical and biomarker assay development and qualification using multitude of bioanalytical methods (i.e., ELISA, MSD, LC-MS, RT-PCR, qPCR, and cell-based assays) to support discovery, preclinical and potential clinical projectsExperience with transfer of assays to CROs (or prior experience within bioanalytical CROs) and troubleshooting technical issuesAbility to independently analyze data and present and share the data with the stakeholdersConversant with writing SOPs and other technical reports as neededExperience within a start-up or small biotech environmentExcellent organizational and communication skills, with an ability to embrace change and multi-task in an extremely fast paced environmentExcellent problem-solving skills and ability to work as a team player in a dynamic environmentPay Range Disclosure Statement$135,000—$182,000 USDThe range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity. This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives. In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being. These include, but are not limited to, company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program. Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.Data Privacy and Your InformationBy submitting your information in applying for a position at Wave (or lawfully on behalf of a candidate as an approved recruiter), you represent that the information you submit (including your name, phone number, email address, address, and resume/CV/work history) is true and accurate, you have the right to share it, and that no part of the Information violates or infringes the rights of any third parties. If you submit information lawfully on behalf of another applicant as an approved recruiter, you confirm that you have the right to so submit. You grant Wave permission to use your information to contact you in connection with this or another position, for interviews, scheduling purposes, travel arrangements, or follow up after a decision on the role has been made.Wave Life Sciences is committed to respecting your privacy. We do not sell or rent personal information to third parties for marketing purposes. Any Personal Information you share with us will be used for business purposes, such as communication with you, and handled in accordance with Wave’s Privacy Policy, Notice, Statements, and Additional Information. Wave collects, evaluates and retains candidate data for the legitimate interest of selecting a candidate for employment or contract purposes. Such data will be kept for no longer than necessary to carry out those purposes, unless you consent for your information to be retained up to an additional three (3) years for consideration for future opportunities at Wave. Any requests related to your Personal Information may be electronically submitted to Wave’s Data Protection Officer at .If you choose to share your demographic background (such as race, gender or sex, national origin, age, disability or veterinary status) by completing the optional survey, your responses will be combined with the answers from other applicants in an aggregated and anonymized form which may be used for equal employment opportunity reporting, diversity and inclusion analysis, and to help us evaluate the effectiveness of our recruiting practices. The information you share will not be used for hiring decisions or provided to hiring managers or interviewers.