Sr. Director, Head, Quantitative Systems Pharmacology

Senior Director, Head of Quantitative Systems Pharmacology (QSP) Responsibilities Develop and implement QSP strategy across priority therapeutic areas and modalities. Embed QSP principles into Moderna’s R&D decision framework, including target validation, animal study design, human dose projection, and mechanism-of-action understanding. Partner with discovery, preclinical, clinical, and platform teams to align quantitative and biological hypotheses with experimental design and portfolio advancement. Champion quantitative and systems-based thinking throughout R&D, representing QSP in cross-functional discussions. Lead design, development, and application of mechanistic models (disease progression, target engagement, immune dynamics, biomarker relationships, etc.) to inform key program decisions. Integrate multi-dimensional data into multi-scale mechanistic models for translation and decision support. Advance innovative modeling approaches and ensure scientific rigor, transparency, and reproducibility in all deliverables. Collaborate closely with Clinical Pharmacology, Translational Medicine, DMPK, research, bioinformatics, clinical development, and platform sciences to design integrated quantitative strategies. Provide QSP input for INDs, IBs, regulatory filings, and Health Authority interactions. Align modeling deliverables with clinical and quantitative pharmacology to enable model-informed decision-making throughout the program lifecycle. Provide scientific and functional leadership for QSP activities across internal teams, matrix partners, external vendors, and academic collaborators. Foster an inclusive, collaborative culture that promotes learning, creativity, and scientific excellence. Oversee outsourced modeling work, budget, and strategic partnerships with CROs and academic collaborators. Represent Moderna in scientific forums, regulatory workshops, and consortia, and publish scientific work in high-impact journals and conferences. Contribute to or lead cross-functional special projects, ad hoc initiatives, or new methodology pilots as needed. Basic Qualifications Ph.D. in systems pharmacology, bioengineering, applied mathematics, pharmacology, or a related quantitative discipline. 10+ years of industry or equivalent experience in QSP/mechanistic modeling, with at least 5 years in oncology and/or immunology. Proven track record of applying translational models to support drug development from preclinical to clinical stages. Deep understanding of PK/PD, systems biology, disease pathway modeling, and biomarker integration. Demonstrated scientific leadership and mentoring of quantitative scientists, preferably across sites, geographies, or matrix settings. Proficiency in MATLAB/SimBiology, Monolix, R, or Python modeling platforms. Strong communication and influencing skills; ability to translate quantitative findings for multidisciplinary and executive audiences. Strategic operational mindset while remaining scientifically hands‑on in a fast-evolving portfolio environment. Experience contributing to regulatory filings and Health Authority interactions using model-informed approaches. Preferred Qualifications Experience in mRNA or novel therapeutic modalities (e.g., gene therapy, biologics, immuno‑oncology). Familiarity with PBPK modeling, virtual populations, or digital‑twin simulation. Experience building scalable modeling infrastructure or toolchains for data integration. Track record of scientific publications and external visibility. Desire to impact a high-growth, transformational company. Benefits & Compensation Salary range: $196,700.00 – $353,400.00. Annual discretionary bonus, equity award, or other incentive compensation subject to company plan eligibility. Best-in-class healthcare coverage and voluntary benefits. Access to fitness, mindfulness, mental health support, and wellness resources. Family planning benefits including fertility, adoption, and surrogacy support. Generous paid time off, volunteer days, sabbatical, global recharge days, and discretionary year-end shutdown. Savings and investment opportunities. Location-specific perks and extras. Equal Opportunities Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military, or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other characteristic protected under applicable law. Moderna is an E‑Verify employer in the United States. #J-18808-Ljbffr