Principal Software Engineer - Signals & Algorithm Interfaces (Python/C++)

We anticipate the application window for this opening will close on - 17 Aug 2026Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact.A Day in the LifeAt Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We’re working a minimum of 4 days a week onsite as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary.As a Principal Software Engineer – Signals & Algorithm Interfaces (Python/C++) you will set the technical direction for how the Affera Signals & Algorithms team's work is brought into the Prism Mapping platform — the architecture that lets new algorithms reach the clinic safely and performantly, and the partnership model that connects algorithm development to production engineering. You'll lead cross-cutting design for real-time signal pipelines, algorithm execution frameworks, and the optimization strategies that let algorithms hit clinical performance targets at scale. You'll partner deeply with the Signals & Algorithms team, hardware engineers, and clinical experts to shape roadmaps, mentor senior engineers across the integration space, and drive root cause on the hardest cross-domain problems — the ones that span signal behavior, system code, and clinical workflow. Your decisions will determine how quickly new clinical capabilities reach physicians, and how reliably they perform in the lab. About the Affera Prism Mapping System The Affera Prism Mapping System is an advanced electrophysiology mapping platform used by physicians to diagnose and guide the treatment of cardiac arrhythmias. It captures and processes signals from inside the beating heart, builds detailed real-time three-dimensional maps of cardiac anatomy and electrical activity, and presents that information to clinicians and mapping specialists during live procedures. Engineers on this team build the software that makes that possible — from the runtime and data pipelines that move signals in milliseconds, to the algorithms that turn raw signals into clinically meaningful information, to the visualization and UI surfaces clinicians rely on in the lab. Primary Responsibilities Lead architecture for algorithm integration on the Prism Mapping platform — real-time signal pipelines, algorithm execution frameworks, and the data contracts that connect hardware, algorithms, mapping, and UI. Define multi-release direction for the algorithm integration architecture and the team partnership model behind it. Set the engineering bar for algorithm-adjacent code on real-time guarantees, determinism, and clinical performance. Lead the design and delivery of major subsystems, cross-cutting architecture, or large technical initiatives. Exercise broad technical judgment in defining approaches to complex system and architectural problems with limited oversight. Drive technical alignment across software, systems, quality, product, and other cross-functional teams. Establish and promote software design patterns, engineering standards, and development best practices. Provide technical leadership across teams through mentoring, design reviews, and guidance on critical engineering decisions. Identify and drive improvements in architecture, development processes, and system design. Shape the technical roadmap and architectural direction for major subsystems or product capabilities. Communicate complex technical tradeoffs, risks, and recommendations to stakeholders across functions. Required Qualifications Bachelor's degree and a minimum of 7 years of relevant experience OR Master’s degree with a minimum of 5 years of relevant experience OR PhD with 3 years relevant experience Preferred Qualifications Deep expertise architecting real-time signal and algorithm pipelines for production systems. Strong understanding of DSP fundamentals and the constraints they impose on system architecture — latency, determinism, sample integrity. Track record of building research-to-production pathways for algorithm work. Deep expertise in Python and C++ and in software architecture for complex, multi-component systems. Proven experience delivering complex, real-time, device-integrated, or networked systems. Experience leading large, complex, cross-functional technical initiatives. Experience defining architecture, standards, or technical direction across multiple components or teams. Experience solving ambiguous, high-impact technical problems spanning multiple domains or subsystems. Experience influencing technical decisions beyond immediate team boundaries. Experience in regulated environments preferred. Advances how the team uses AI tools — introduces new approaches that raise team productivity and quality. AfferaSWFY27 AfferaSWFY27map #LI-MDT For Baccalaureate degrees earned outside of the United States, a degree that satisfies the requirements of 8 C.F.R. § 214.2(h)(4)(iii)(A) is required.Physical Job RequirementsThe above statements are intended to describe the general nature and level of work being performed by employees assigned to this position, but they are not an exhaustive list of all the required responsibilities and skills of this position. The physical demands described within the Responsibilities section of this job description are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. For Office Roles: While performing the duties of this job, the employee is regularly required to be independently mobile. The employee is also required to interact with a computer, and communicate with peers and co-workers. Contact your manager or local HR to understand the Work Conditions and Physical requirements that may be specific to each role.U.S. Work Authorization & Sponsorship At Medtronic, we are committed to fostering an environment where employees can thrive and make a meaningful impact. In alignment with our enterprise-wide workforce planning approach, U.S. work authorization sponsorship (H-1B, TN, J, etc.) is offered exclusively for Principal-level roles and above, where specialized expertise aligns with long-term business needs. Roles below the Principal level require candidates to possess unrestricted U.S. work authorization at the time of hire and for the duration of employment. ‌Recruitment Fraud AlertWe are aware of phishing scams targeting job seekers. Please keep the following in mind: Apply only through official Medtronic channels. All legitimate Medtronic recruiting communications come from approved Medtronic platforms and official @medtronic.com email addresses. Medtronic will never ask for payment or sensitive personal information (such as bank account or Social Security details) during early stages of the hiring process. Any such requests are not legitimate. If you receive a suspicious message claiming to be from Medtronic, do not respond, click links, or open attachments. If you have any questions, concerns regarding the authenticity of a communication alleged to have been made by or on behalf of Medtronic, please contact us immediately at View email address on click.appcast.io. ‌Benefits & CompensationMedtronic offers a competitive Salary and flexible Benefits PackageA commitment to our employees lives at the core of our values. We recognize their contributions. They share in the success they help to create. We offer a wide range of benefits, resources, and competitive compensation plans designed to support you at every career and life stage.Salary ranges for U.S (excl. PR) locations (USD):$152,800.00 - $229,200.00This position is eligible for a short-term incentive called the Medtronic Incentive Plan (MIP).The base salary range is applicable across the United States, excluding Puerto Rico and specific locations in California. The offered rate complies with federal and local regulations and may vary based on factors such as experience, certification/education, market conditions, and location. Compensation and benefits information pertains solely to candidates hired within the United States (local market compensation and benefits will apply for others). The following benefits and additional compensation are available to those regular employees who work 20+ hours per week: Health, Dental and vision insurance, Health Savings Account, Healthcare Flexible Spending Account, Life insurance, Long-term disability leave, Dependent daycare spending account, Tuition assistance/reimbursement, and Simple Steps (global well-being program).The following benefits and additional compensation are available to all regular employees: Incentive plans, 401(k) plan plus employer contribution and match, Short-term disability, Paid time off, Paid holidays, Employee Stock Purchase Plan, Employee Assistance Program, Non-qualified Retirement Plan Supplement (subject to IRS earning minimums), and Capital Accumulation Plan (available to Vice Presidents and above, or subject to IRS earning minimums).Regular employees are those who are not temporary, such as interns. Temporary employees are eligible for paid sick time, as required under applicable state law, and the Employee Stock Purchase Plan. Please note some of the above benefits may not apply to workers in Puerto Rico.Further details are available at the link below:Medtronic benefits and compensation plansIt is the policy of Medtronic to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Medtronic will provide reasonable accommodations for qualified individuals with disabilities.If you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. Medtronic will consider for employment qualified job applicants with arrest or conviction records in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.SummaryLocation: Newton, Massachusetts, United States of America; Mounds View, Minnesota, United States of AmericaType: Full time