Director, Investor Relations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Join Amylyx at a pivotal moment of growth and visibility as our Director, Investor Relations—a high-impact role at the center of our corporate story, strategy, and market presence. In this position, you’ll work side-by-side with the VP of Investor Relations & Communications and partner closely with our senior leadership team—including our co-CEOs, CFO, CMO, and CCO—to shape how the investment community understands and values our mission. You’ll serve as a strategic advisor and storyteller, helping to translate complex science and financial performance into a clear, compelling narrative that resonates with investors and analysts. You’ll play a key role in strengthening our investor engagement program, building meaningful relationships, and influencing how Amylyx is perceived in a dynamic and evolving healthcare landscape. Responsibilities * Support the development and execution of investor relations plans and initiatives aligned with corporate goals during a period of dynamic growth, while helping to define and drive a forward-looking 12–24 month IR strategy in partnership with senior leadership and the Board, ensuring alignment with long-term corporate objectives * Engage with the investment community, including healthcare investors and equity research analysts, represent Amylyx at events, and, over time, become a primary relationship owner for select sell-side analysts and new buy-side accounts * Write quarterly and annual results communications, including financial results press releases, annual reports, conference call scripts, key messages, Q&As, and other documents to communicate to investor and analyst audiences * Partner with colleagues to prepare documents for filings and disclosures to be compliant with SEC regulations (i.e., 8-Ks, 10-Ks, 10-Qs, proxies); in certain circumstances, lead creation of documents for filings * Write and create investor-facing materials, including press releases, presentations for investor meetings, key message documents, Q&As, and content for website; lead and make update as appropriate * Partner with leadership and other colleagues to ensure consistency of messaging * Participate in one-on-one meetings, bus tours, conferences, and non-deal roadshows, and lead follow-up when appropriate * Respond to requests for information from external stakeholders, including shareholders, in a timely manner * Review and analyze analyst research and models, consensus estimates, and market-related trends impacting valuation and perception; summarize market sentiment on Amylyx and continue to manage consensus * Analyze peer companies’ communications, peer sell-side research, industry and communication trends and compile reports for leadership that support investor interactions * Partner with Senior IR and Communications Operations Specialist who manages active IR calendar/schedules and prepares background information on investors in advance of meetings; assist with scheduling, preparations, and investor tracking when needed * Support the overall Investor Relations function, including assisting with day-to-day needs and long-term special projects Required Qualifications

• Bachelor’s degree required
• 10+ years of experience, including 5+ years of experience on commercial

biotech or pharma team * Background in Investor Relations, Corporate Finance, Equity Research, Buy-Side, or Consulting preferred * Strong understanding of financial modeling and how analysts assess company performance and valuation * Knowledge of SEC regulations, disclosure requirements, and management of material non-public information

• Executive presence with the ability to influence and counsel senior leaders
• Exceptional written, verbal, and presentation skills across diverse internal

and external audiences * Ability to translate complex scientific, clinical, and financial information into clear, compelling messaging

• Strong understanding of investor priorities and market expectations
• Sound judgment and composure in high-pressure environments

Work Location and Conditions * At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. * Preference will be given to candidates who reside in the New England/NYC regions and can be in person on an as needed basis. * When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range

$204,000—$230,000 USD

To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn [ To return to our website please click here [ Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.