Scientist, Protein Design

The RoleModerna is seeking a Scientist to provide technical experience for in vitro selection and cell-surface screening of viral and bacterial antigens. This role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates.The Scientist will provide technical leadership through direct involvement in the design and execution of complex in vitro selection campaigns, setting experimental strategy and partnering closely with computational protein design teams to ensure designs are evaluated and refined at scale. In addition to antigen-focused efforts, this individual will be cross-trained to support screening of de novo designed proteins, including minibinders and VHHs, as a shared discovery resource.The Scientist will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines. Here’s What You’ll DoLead execution of in vitro selection and cell-surface screening campaigns, providing technical leadership through direct involvement in experimental design and execution.Design and run high-throughput mammalian display campaigns for complex, multimeric glycoproteins.Build and deploy scalable screening systems that replace resource-intensive plate-based assays.Develop and operationalize advanced in vitro selection and directed-evolution capabilities, including novel selection pressures and expanded mammalian display modalities.Serve as a key experimental partner to computational protein design teams, generating high-quality datasets and actionable design feedback.Represent in vitro selection capabilities in cross-functional discovery and platform discussions.Here’s What You’ll Need (Basic Qualifications)PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering, or a related field.Demonstrated ability to drive complex screening campaigns end-to-end.Deep expertise in mammalian display systems, high-throughput selection strategies, and experimental assay design.Scientific independence, judgment, and ownership consistent with a Scientist role.Here’s What You’ll Bring to the Table (Preferred Qualifications)Expertise with antigen expression and engineering (e.g., strategies around folding, trafficking, cleavage, stability, and glycan impacts).Strong capabilities in library design and construction (site-saturation, combinatorial, error-prone, DNA assembly), plus NGS-based readouts and quantitative enrichment analysis.A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.Pay & BenefitsAt Moderna, we believe that when you feel your best, you can do your best work. That’s why our benefits and well-being resources are designed to support you—at work, at home, and everywhere in between.Competitive healthcare, plus voluntary benefit programs to support your unique needsA holistic approach to well-being, with access to fitness, mindfulness, and mental health supportFamily planning benefits, including fertility, adoption, and surrogacy supportGenerous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdownSavings and investments to help you plan for the futureLocation-specific perks and extrasThe salary range for this role is $109,200.00 - $174,600.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs. The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.About ModernaSince our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Equal OpportunitiesModerna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. AccommodationsWe’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at View email address on click.appcast.io. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant’s ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license. -SummaryLocation: Cambridge, Massachusetts; ResearchType: Full time