Contract Research Associate/Sr. Research Associate (Discovery Chemistry)

Contract Research Associate/Sr. Research Associate (Discovery Chemistry) Perform routine laboratory functions and maintain, calibrate, and set up laboratory instruments and equipment. Perform synthesis of chemically modified oligonucleotides and peptides using automated instruments. Experience with MerMade/AKTA oligonucleotide synthesizers, and Liberty Blue/Aaptec peptide synthesizers desirable. Perform multi-step small molecule reactions to generate ligands for downstream bioconjugation projects. Work closely with senior scientists to design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes. Data management and documentation: Maintain accurate, organized experimental records and reagent inventories in electronic lab notebooks (ELNs) on a regular basis. Act as member of a multidisciplinary research team, assisting with development of project strategy, analysis and communication of complex data.

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Requirements: B.S./M.S. in chemistry or related fields with 0-4 years of relevant experience, preferably in an industrial setting. Experience in organic chemistry and multi-step organic synthesis Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is preferred Experience using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase, Ion exchange chromatography (HPLC/UPLC), ESI-MS and MALDI-TOF Mass Spectrometry (LC-MS) is a plus. Experienced in using electronic lab notebooks (ELNs) for data documentation and management. #J-18808-Ljbffr Commonwealth Sciences, Inc.