Scientist Cell Therapy (R&D)

---This is a hands-on, laboratory-focused position.---Typical Accountabilities - Develop routine drug discovery research experiments and analytical studies to identify and validate potential novel drug targets, applying diverse methodologies, with minimal supervision.- Conduct experiments and interpret results by using established scientific methodologies and tools.- Modify or improve existing research processes and systems to better align with experimental objectives.- Assess and report experimental data with minimal guidance, ensuring clarity, relevance, and connection to the broader drug discovery context.- Present and defend experimental findings during follow-up meetings or in relevant forums.- Manage personal workload efficiently to achieve agreed-upon targets within specific time limits and quality standards, while also providing routine updates on progress.- Provide technical mentorship to team members on experimental procedures and allocate administrative tasks when necessary.- Collaborate with project teams to facilitate seamless communication and data sharing within the team.- Search for information which may improve research methodology and procedures.- Ensure work is performed in compliance with Safety, Health & Environment (SHE), quality, and regulatory requirements, including laboratory standards (GLS). Minimum Qualifications: Essential:

• Bachelor’s degree (or equivalent 3-4 years of experience) experience in a relevant field with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology.
• 2+ years of industry experience.

• Extensive in vivo skills including animal handling, syngeneic murine, xenograft and PDX tumour models, standard routes of dosing and engraftment, tissue processing, PK/PD and efficacy studies;
• Proficiency in tail vein dosing; Well-developed understanding of molecular and cellular biology, immunological assays;
• Effective interpersonal skills; Ability to develop, implement, and troubleshoot experiments independently.

Desirable:

• Experience with a range of in vitro assays, including but not limited to ELISA, multicolor flow cytometry;
• In vitro and in vivo experience with murine T cells;
• Basic experience developing cellular therapies including CAR-T/ CAR-NK, TCR-T, and/ or TIL therapies;
• Background in drug discovery and development in the pharmaceutical industry;
• Experience with complex in vivo systems, including but not limited to orthotopic xenograft models, humanized mice, in vivo imaging of luciferase labelled tumor models.

Key Relationships Internal: Colleagues, senior staff and management; AZ project teams. External: External scientific community.

Date Posted

Closing Date

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