Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Scientific Data Scientist

Oakwell Hampton Group

We are a fast-growing startup backed by an Nvidia VP, working alongside top AI labs and global tech companies to build the foundational data layer that will power the next generation of AI-driven drug discovery.

We are conducting a confidential search for a senior scientific leader to oversee and execute our data strategy. We need a scientist who can lead—not just manage—and who brings a wealth of "big pharma" clinical experience to the table.

The Role

As our Principal Scientific Data Scientist, you will ensure our data is world-class, rigorous, and ready to train the AI models that will discover tomorrow's breakthrough therapeutics.

You will:

  • Lead the day-to-day operations and strategic direction of our biological data layer across multiple concurrent projects.
  • Leverage your deep expertise in bioinformatics and Real-World Data (RWD) to translate complex clinical needs into precise data specifications.
  • Draw heavily on your background in global pharma clinical programs to personally examine, validate, and enforce the scientific rigor of our data generation pipelines.
  • Manage a distributed network of PhD-level expert contractors to recruit, brief, review, and iterate on scientific data generation.

The Ideal Candidate

  • Education: Ph.D. in Bioinformatics, Computational Biology, Pharmacology, or a closely related life sciences field.
  • Domain Expertise: Extensive experience working within global pharmaceutical companies, with a strong focus on clinical programs and translational research.
  • Technical Skills: Deep bioinformatics expertise with a proven track record of handling Real-World Data (RWD), multi-omics datasets, and clinical trial data analysis pipelines.
  • Leadership: Demonstrated experience leading computational teams, managing complex data operations, and taking ownership of end-to-end data quality.
  • Mindset: Detail-obsessed, fast-moving, and possessing a "builder" mentality—you are a scientist first who understands the biology and can build the infrastructure to support it.

Why Join? This is an opportunity to join a founding team with real equity and make a massive impact at the most exciting intersection in biotech today: AI and drug discovery.

If you are a seasoned pharma scientist who is tired of big pharma bureaucracy and wants to build infrastructure that matters, we want to hear from you

Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Principal Scientific Data Scientist in San Jose, CA vacancy
  •  ...companies to build the foundational data layer that will power the...  ...search for a senior scientific leader to oversee and execute...  ...our data strategy. We need a scientist who can lead—not just manage—...  ...table. The Role As our Principal Scientific Data Scientist, you... 
    Principal
    Scientific
    For contractors

    Oakwell Hampton Group

    Santa Clara, CA
    3 days ago
  • $220k - $329.3k

     ...The Position Genentech, Inc. seeks a Principal Data Scientist at its South San Francisco, CA location. Duties: Apply statistical theory...  ..., and identify data quality issues. Lead research on scientific approach and utilize state-of-art methodologies to analyze... 
    Principal
    Scientific
    Local area
    Remote work
    3 days per week

    F. Hoffmann-La Roche Ltd

    San Jose, CA
    6 hours ago
  • $143k - $286k

     ...Position Summary... As a Principal Data Scientist at Walmart, you will define and execute the data science roadmap for the experimentation...  ...large-scale data systems, and AI evaluation. You will own the scientific direction behind experiment reporting, dashboards,... 
    Principal
    Scientific
    Full time
    Temporary work
    Part time

    Walmart

    Sunnyvale, CA
    3 days ago
  •  ...Azure Principal Data Engineer Work mode: Hybrid Onsite Location(s): Valencia, CA, US, 91355 Additional Location(s): US-CA-Santa Clara...  ...Collaboration - Winning Spirit - High Performance At Boston Scientific, we'll give you the opportunity to harness all that's within... 
    Principal
    Scientific
    Full time
    Work at office
    Local area
    Relocation package
    3 days per week

    Boston Scientific

    Santa Clara, CA
    4 days ago
  •  ...The Global e-commerce Data Science team aims to maximize the efficiency of e-commerce transactions, lead product decision-making iterations...  ..., and achieve sustainable growth in revenue with data and scientific methods, through quantitative techniques such as mathematical... 
    Scientific

    Tik Tok

    San Jose, CA
    2 days ago
  •  ...generations to come. Join Roche, where every voice matters. The Position Roche Sequencing Solutions is expanding with a Principal Data Scientist to lead and help drive forward R&D activity by providing a deep level of insight into experimental data, its... 
    Principal
    Local area
    Relocation package

    Roche

    Santa Clara, CA
    10 days ago
  • A leading tech company in Sunnyvale is seeking a Principal Data Scientist to architect and implement end-to-end machine learning systems. This role involves designing scalable, low-latency model serving infrastructure and building automation solutions for predictive autoscaling... 
    Principal

    Experimentation Jobs

    Sunnyvale, CA
    2 days ago
  • $128k - $282k

    F. Hoffmann-La Roche Gruppe is seeking a Principal Data Scientist in Santa Clara, CA, to lead R&D activities by providing in-depth insights into experimental data. The ideal candidate will possess a PhD and 5+ years of experience in data handling, statistical methods,... 
    Principal

    F. Hoffmann-La Roche Gruppe

    Santa Clara, CA
    5 days ago
  •  ...Data Scientist We are seeking a seasoned Data Scientist to collaborate closely with cross-functional teams. Your role will be pivotal in shaping our product strategy using robust scientific methodologies. Leveraging your expertise in statistical analysis, machine learning... 
    Scientific

    Aven, Inc.

    Campbell, CA
    21 days ago
  •  ...professional IT Consulting services in the US. We are actively seeking Principal Big Data Engineer for one of our client, Please share your resume...  ...use cases, communicate effectively with R&D teams and data scientists to resolve bottlenecks, and design scalable data processing... 
    Principal

    Rootshell Enterprise Technologies

    Santa Clara, CA
    2 days ago
  • $110k - $190k

     ...Role Overview We are seeking a Data Scientist to work at the intersection of laboratory science and data-driven software systems....  ...scientists, engineers, and business stakeholders to translate scientific workflows into productized analytical tools and data-informed... 
    Scientific
    Flexible hours

    Covalent

    Sunnyvale, CA
    2 days ago
  •  ...Global Tech’s Reliability Engineering group builds intelligent, data-driven platforms ensuring availability, performance, and...  ...cloud infrastructure worldwide. What Will You Do? As a Principal, Data Scientist at Walmart, you will architect and implement end-to-end ML... 
    Principal
    Worldwide

    Experimentation Jobs

    Sunnyvale, CA
    1 day ago
  • $158.6k - $181k

     ...Principal Data Scientist, AI Foundations Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually personalizing every credit card offer using statistical modeling and the relational database, cutting edge technology... 
    Principal
    Full time
    Part time
    Local area
    Flexible hours

    Capital One

    San Jose, CA
    4 days ago
  •  ...Role: Data Scientist - Machine Learning Focus (This role is open to US Citizens, Green Card...  ...business use cases, • Strong skills in scientific data analyses, modeling, visualization...  ...) • Dimension Reduction techniques (Principal Component analysis, Singular Value... 
    Scientific
    Full time
    Contract work
    Immediate start
    Remote work
    Visa sponsorship
    Relocation package

    Adidev Technologies Inc

    San Jose, CA
    3 days ago
  • $219k - $374.4k

     ...TikTok Shop - Data Scientist - AI Location: San Jose Employment Type: Regular Job Code: A234833 Responsibilities The Global...  ..., and achieve sustainable growth in revenue with data and scientific methods, through quantitative techniques such as mathematical... 
    Scientific
    Temporary work
    Local area

    Tik Tok

    San Jose, CA
    6 hours ago
  • $143k - $286k

     ...Position Summary... The Reliability Engineering group at Walmart Global Tech builds intelligent, data-driven platforms that ensure the availability, performance, and efficiency of Walmart's enterprise and e-commerce systems at massive scale. The team leverages large... 
    Principal
    Full time
    Temporary work
    Part time
    Worldwide

    Walmart

    Sunnyvale, CA
    3 days ago
  • $143k - $286k

     ...Position Summary... About Walmart Data Ventures Walmart Scintilla is a commercial data and AI platform powering the suppliers...  ...industry benchmarks. About the Role We are seeking a Principal Data Scientist to shape the future of Generative AI and Agentic AI at... 
    Principal
    Full time
    Temporary work
    Part time

    Walmart

    Sunnyvale, CA
    4 days ago
  • $136.8k - $292.6k

     ...Responsibilities About the Team The primary role of a Data Scientist on the Governance team is to conduct deep analysis of user behavior...  ...conduct root cause analysis for metric anomalies. 3. Conduct scientific evaluation using statistical methods, including A/B testing... 
    Scientific
    Temporary work
    Local area

    Tik Tok

    San Jose, CA
    6 hours ago
  •  ...Principal, Data Scientist Multiple locations Bentonville, AR: $110,000 - $220,000/yr Sunnyvale, CA: $143,000 - $286,000/yr Regular/ Permanent Salaried Position Summary... About Team: The data science team at the Enterprise Business Services Pillar at Walmart Global... 
    Principal
    Permanent employment
    Full time
    Temporary work
    Part time
    Flexible hours

    Walmart

    Sunnyvale, CA
    2 days ago
  • $143k - $286k

     ...Position Summary... What you'll do... The Principal Data Scientist in the Data Science team will play a crucial role as an architect, leading AI explorations, research, algorithmic solution creation, and fast prototyping aimed to deliver impactful initiatives within... 
    Principal
    Full time
    Temporary work
    Part time
    Shift work

    Walmart

    Sunnyvale, CA
    4 days ago
  • $185.2k - $299.48k

     ...We don't just follow industry trends; we create them. As a Sr Principal Engineer focused on the Agent, you will be at the center of...  ...Career: We are seeking a visionary Senior Principal AI / Data Scientist to join our Autonomous Digital Experience Management (ADEM) team... 
    Principal
    Full time
    Work at office
    Shift work

    Palo Alto Networks

    Santa Clara, CA
    4 days ago
  • $55 per hour

     ...Team Introduction: Join our team and leverage the power of data science to directly safeguard content, users, and privacy on TikTok...  ...identify and analyze security incidents; - Learn to apply statistical scientific methods, including A/B testing, causal inference, regression... 
    Scientific
    Hourly pay
    Internship
    Local area
    Worldwide

    Tik Tok

    San Jose, CA
    3 days ago
  • $136.8k - $292.6k

     ...monetization strategies and OGC verticals. The primary role of a Data Scientist for our Data team is to conduct deep analysis of user...  ...growth opportunities through analyses, experiments, or other scientific methods, and influence directions for improvement. Qualifications... 
    Scientific
    Temporary work
    Local area
    Overseas

    Tik Tok

    San Jose, CA
    4 days ago
  • $35 per hour

     ...Responsibilities Join our team and leverage the power of data science to directly safeguard content, users, and privacy on TikTok...  ...and analyze security incidents; - Learn to apply statistical scientific methods, including A/B testing, causal inference, regression analysis... 
    Scientific
    Hourly pay
    Summer work
    Internship
    Local area
    Worldwide

    Tik Tok

    San Jose, CA
    3 days ago
  •  ...guide** end-to-end ML systems covering data sourcing, feature engineering, model training...  ...*, guiding senior engineers and applied scientists to build depth and expertise. **...  ...high-uncertainty environments. The ideal Principal has a deep technical science and engineering... 
    Principal

    Walmart Canada

    Sunnyvale, CA
    2 days ago
  • $256k - $356k

    Google Inc. is looking for a Principal Engineer in Sunnyvale, CA, to lead innovative solutions for data center operations and AI infrastructure challenges. The ideal candidate will possess a Master's degree and 15 years of relevant experience, focusing on driving technical... 
    Principal
    Full time

    Google Inc.

    Sunnyvale, CA
    4 days ago
  •  ...Principal Engineer of Data Science Sunnyvale, CA or Bentonville, AR (Relocations are welcome and there is a relocation package only for Bentonville...  ...within a highly cross-functional team, including data scientists, machine learning engineers, product managers, and UX... 
    Principal
    Permanent employment
    Full time
    Relocation
    Relocation package

    RIT Solutions

    Sunnyvale, CA
    10 days ago
  •  ...HPE Labs - Principal AI and Machine Learning Research Engineer This role has been designed...  ..., protect, analyze, and act on their data and applications wherever they live, from...  ..., balancing significant technical and scientific contributions with the ability to bring... 
    Principal
    Scientific
    Work experience placement
    Work at office
    Immediate start

    Hewlett Packard Enterprise

    Milpitas, CA
    6 hours ago
  • $167k - $270.5k

    Palo Alto Networks, Inc. is seeking a Principal IT Data Engineer in Santa Clara, California. This role involves architecting and maintaining data transformations and analytical solutions essential for business objectives. The ideal candidate will leverage their extensive... 
    Principal

    Palo Alto Networks, Inc.

    Santa Clara, CA
    3 days ago
  •  ...Principal Data Scientist: Associate AI Experience We are seeking a Principal Data Scientist to provide technical leadership and long-term vision for next-generation AI systems and platforms. This senior individual contributor will drive breakthrough system design and... 
    Principal
    Full time
    Temporary work
    Part time
    Home office

    Walmart

    Sunnyvale, CA
    6 hours ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Scientific Data Scientist. Be the first to apply!