Head of Project Management

OverviewThis role will partner with CMC Technical Leads to drive the planning, coordination, and execution of complex CMC development programs across the Technical Operations and Quality (TOQ) organization. The role serves as the operational leader for assigned projects, developing and maintaining integrated project plans, managing risks and dependencies, driving cross-functional alignment, and ensuring timely delivery of program objectives. The successful candidate is a proactive, self-motivated project manager with strong organizational, communication, and problem-solving skills who leverages project management tools, metrics, and best practices to enable quality decision-making, improve team effectiveness, and support successful project outcomes.Key ResponsibilitiesLead day-to-day project management and execution for multiple CMC development programs, ensuring alignment across internal functions and external partnersDevelop, maintain, and drive integrated project plans that capture key activities, milestones, deliverables, dependencies, resource requirements, and critical pathsCoordinate and manage cross-functional execution with CMC Technical Leads across Manufacturing, Process Sciences, Analytical Science, Supply Chain, Quality, Regulatory Affairs, and external partners, ensuring timely completion of project deliverablesProactively identify project risks, issues, assumptions, and dependencies; facilitate mitigation planning, issue resolution, and escalation of critical decisions as neededFacilitate effective cross-functional team meetings, driving accountability through clear action-item tracking, decision documentation, follow-up, and communication of outcomes.Build strong partnerships and influence stakeholders across disciplines to align priorities, resolve competing needs, and achieve program objectivesUtilize project management tools and systems to maintain project visibility, support decision-making, track performance metrics, and communicate program statusDrive continuous improvement of project management processes, tools, templates, and team operating practices to enhance efficiency, consistency, and execution excellence across the organizationQualificationsBachelor's degree or equivalent working experience preferred.Minimum 5 years of direct project management experience in the biotechnology, pharmaceutical, or related industry. Experience supporting CMC development programs (preclinical through commercial readiness) strongly preferred.Demonstrated success managing complex, cross-functional projects involving multiple stakeholders, competing priorities, and evolving timelinesStrong analytical, organizational, and problem-solving skills with the ability to connect operational details to broader program objectivesExcellent interpersonal, communication, facilitation, and presentation skillsExperience utilizing project management tools and systems such as Smartsheet, , Planisware, Microsoft Project, or equivalent platformDemonstrated commitment to continuous improvement through the application of project management best practices, process improvements, and operational excellence initiativesAbout AlnylamWe are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: