Comptroller/Finance/Accounting

Programmable Medicine is a pre-revenue, clinical-stage biotechnology company focused on discovering and developing innovative therapies for patients with serious diseases. The company operates across multiple legal entities and partners with external CROs, CMOs, and research institutions globally. Backed by leading venture capital investors, Programmable Medicine is building a scalable finance function to support rapid growth and pipeline advancement.
The Controller will be a key member of the finance leadership team, responsible for building and overseeing the company's accounting operations, financial reporting, and internal controls. This role requires deep technical accounting expertise, hands-on execution, and experience supporting venture-backed, pre-commercial life sciences companies with complex entity structures.
The ideal candidate thrives in a fast-paced, evolving environment, can operate both strategically and tactically, and has experience partnering closely with FP&A, Legal, Tax, and external auditors. Must be able to work on-site a minimum of 4 days per week.
Accounting & Close

Own the monthly, quarterly, and annual close processes across multiple legal entities
Ensure accurate and timely preparation of financial statements in accordance with U.Develop and maintain accounting policies, procedures, and documentation
Oversee general ledger activity, account reconciliations, and journal entries
Technical Accounting

Manage complex accounting areas including:
Equity and share-based compensation (ASC 718)
R&D expense accruals and clinical trial accounting
Manage technical accounting for complex capital structures, including debt, warrants, embedded derivatives, and related valuation considerations.
Prepare technical accounting memos and support conclusions with appropriate documentation

Audit, Tax & Compliance

Serve as primary point of contact for external auditors and advisors
Manage annual financial statement audits
Coordinate income tax provision support and entity-level compliance and tax returns with external tax firms
Ensure compliance with statutory reporting requirements across domestic and international entities
Implement and optimize accounting systems, processes, and internal controls as the company scales
Partner with FP&A to ensure alignment between actuals, forecasts, and budgets
Build, mentor, and manage a growing accounting team
Collaborate closely with Legal on entity management, contracts, and equity matters
Support due diligence activities related to financings, partnerships, and potential transactions
Act as a trusted business partner to R&D, Operations, and Executive Leadership
Bachelor's degree in accounting or finance (CPA strongly preferred)
A minimum of 12 years of progressive accounting experience, with at least 3 years of biotech or life sciences
Exposure to international subsidiaries and intercompany accounting
GAAP knowledge and technical accounting skills
Hands-on experience leading audits and working with external advisors
Advanced Excel skills and experience with accounting systems
Big Four or national public accounting firm background
Experience supporting venture-backed or high-growth companies
Prior experience building accounting infrastructure from an early stage
We have a comprehensive total compensation package including fully paid medical, dental, and vision benefits for you and your family. We want all of our employees to have the opportunity to become shareholders and offer new hire stock options. The Company also offers participation in the annual bonus program. We consider various factors when determining the base compensation, including market survey data, experience, qualifications, and geographic location, which means that the actual compensation may vary.