Research fellow - and biology

About Arc Institute Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.
Virtual Cell Initiative : Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials.
Alzheimer's Disease Initiative : Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes.
We are seeking an In Vivo Research Associate II to join the Konermann Laboratory at the Arc Institute.You will collaborate closely with experienced scientists to advance in vivo projects focused on understanding brain development.
This project builds on previous work in genome-scale CRISPR screening (Konermann et al., 2025) and aims to combine modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function. The ideal candidate will have experience in animal handling and colony management, intracerebral injections, sample processing for single-cell RNA sequencing and spatial pipelines, and imaging. This position offers an excellent opportunity for candidates considering PhD programs, as it involves participation in all stages of a research project under the guidance of an experienced scientist.
You love science and learning. Whether it's a new field or a new bench technique, you stay curious and enjoy stepping outside your comfort zone.
You're careful and diligent about documentation and good lab practice, and you like keeping things organized.
You collaborate and help others. Science is a team effort, and you take the initiative to pitch in.
Comply with federal, Arc, and local IACUC/AAALAC regulations governing animal research
Follow Arc's standards for code of conduct, safety, and the handling of hazardous materials, biological materials, and controlled substances
Analyze and present data at subgroup meetings and seminars
Maintain an organized, detailed lab notebook
BS with 2+ years of relevant experience, or MS, in molecular biology, neuroscience, or another relevant field. Relevant experience includes independent lab work during undergraduate studies
Strong experience working with laboratory animals, including handling, restraint, and procedures under an approved protocol (intracranial, IV, and IP injections, as well as perfusions)
Ability to work some weekends as needed (days off can be swapped for weekdays
Prior experience with cloning via Gibson assembly or Golden Gate protocols (library cloning experience is a plus)
Computational skills (Python or R)