Chemist, Biologist - No

About the Role You’ll work closely with the founders and a small team from MIT, Harvard Medical School, Baker Lab, and Radical Numerics.
For the right person, this will likely be one of the steepest learning curves of their career. This is a place where your role can change every few months. If you demonstrate strong judgment, you will rapidly gain additional scope, whether it’s a new workflow, new modality, new program, or a new critical task to own. We’ll provide you with context, trust, and the resources to move fast.
What You’ll Do Design, run, and optimize cell-based assays for GPCR pharmacology, including FLIPR calcium flux, cyclic AMP, IP1/IP accumulation, beta-arrestin recruitment, receptor internalization, membrane potential, and related fluorescence or luminescence readouts.

Develop robust assay workflows across transient and stable cell systems, including cell culture, plating density, receptor expression, ligand stimulation, antagonist/inhibitor formats, time-course design, dose-response curves, and assay window optimization.

Run high-quality fluorescence, luminescence, HTRF/TR-FRET, BRET, ELISA, plate-reader, and imaging-based assays to characterize potency, efficacy, selectivity, kinetics, bias, and reproducibility.

Work closely with chemists and automation engineers to connect synthesis outputs to biological activity.

Who You Are You may come from cell biology, pharmacology, molecular biology, chemical biology, neuroscience, bioengineering, screening, assay development, or a nontraditional background. What matters is your ability to generate reliable biological data from complex cell-based systems.

You proactively troubleshoot workflows. When an assay fails, a plate looks unusual, a curve is noisy, or a compound result does not make sense, you systematically identify the root cause and improve the workflow before the same issue repeats.

You have hands‑on experience running cell-based assays. Experience with GPCR signaling assays such as FLIPR calcium flux, cAMP, IP1/IP accumulation, beta‑arrestin, or receptor trafficking is helpful but not required. We can teach specific assay formats.

Pay & Benefits $120,000-$1650,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

$500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.

Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.

You will also have access to HSA, FSA, and 401K plans.

Healthy dinners with the team are provided daily.

We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

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