Research Fellow - Immunology Sciences

Science

The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and education in neuroscience, cardiovascular biology, immunology, and stem cell biology. Home to notable leaders in science and biomedicine,

All of its approximately 600 members are aligned in their mission to carry out or support science that overcomes disease. Located in an award-winning building at the Mission Bay Campus, Gladstone offers a competitive salary and benefits program. Consider Gladstone and make a difference in human health.

We are seeking a highly motivated, curious, and creative Research Associate I to join our discovery team that is focused on investigating the mechanisms of age-dependent neurodegeneration and neuroinflammation to better understand disease biology and to identify novel therapeutic opportunities for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). One key area of research involves modeling neuroinflammation and the role it plays in neurodegeneration by focusing on the role of glia, and especially neuron-microglial interactions, to better understand the mechanistic contributions to disease pathogenesis. We are also interested in the role that protein homeostasis plays in aging and in disease, and a main research focus in the lab is on the autophagy-lysosome pathway (ALP). This position offers an opportunity to participate in cutting-edge research and use high throughput (HTS) and high content (HCS) image-based screening by robotic microscopy and computational approaches including machine learning in glial and neuron cell types derived from human patient induced pluripotent stem cells (iPSC) to identify disease mechanisms and therapeutic targets.

The candidate will join a dynamic multidisciplinary research team and we wish to find someone with a collaborative and pioneering work ethic and genuine enthusiasm and curiosity to learn. Many of our projects are carried out in collaboration with industry partners to develop new therapeutics based on the targets we identify.

Perform standard molecular biology techniques such as DNA preparation and restriction enzyme digestions, DNA cloning and plasmid construction, gel electrophoresis, and qPCR.

Perform manual curation and statistical analysis of imaging data using basic computational skills (R-analysis, Galaxy pipeline workflow construction, Image J/Fiji) to generate high quality datasets for machine learning or publication.

Review data, prepare figures and reports, and communicate results to scientists and the general public in team and departmental meetings and conferences.

Maintain and complete documentation of all experimental procedures in written and electronic lab notebooks.

Perform other duties as requested, be a team player, and be a mindful and collaborative lab citizen.

S. in Biology, Biotechnology, or related field or equivalent combination of education and experience.

0-2 years of research experience including basic biology skills and excellent cell culture sterile technique.

Experience with cell culture, microscopy, and cellular and molecular biology techniques.

Familiarity with image processing pipelines, such as Nextflow.

Familiarity with Python.

Willingness to learn new skills and take on complex new challenges beyond your comfort level with an enterprising “can-do”, creative, curious, and open-minded attitude.

People-work with talented, committed, and supportive teammates within an organization that values each member of its community.

A meaningful place to grow and learn-whether it’s your professional skills or scientific knowledge, we have the resources and environment to advance either so you can better support Gladstone’s mission to drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and excellent environment.

Excellent benefits-generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.

Gladstone is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, sex, religion, national origin, ancestry, age, marital status, medical condition, physical or mental disability, veteran status, sexual orientation, or any other non-job related characteristic. Gladstone Institutes drives innovative disease-oriented research through pioneering scientific paths and interdisciplinary collaboration, while mentoring future leaders in a dynamic environment.

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