Clinical Trials Nurse- Full Time

Clinical Research Nurse 2
Business Unit: Rush Medical Center
Hospital: Rush University Medical Center
Work Type: Full Time (Total FTE between 0.9 and 1.0)
Shift: Shift 1
Pay Range: $43.60 - $69.43 per hour. Rush salaries are determined by many factors including, but not limited to, education, job-related experience and skills, as well as internal equity and industry specific market data. The Clinical Research Nurse 2 (CRN 2) is an experienced research nurse who provides clinical care to participants and supports the conduct of clinical research studies under the direction of a Principal Investigator (PI). As part of a collaborative research team, the CRN 2 contributes to study planning, assists with participant recruitment, eligibility screening, informed consent, and ensures protocol adherence throughout the study lifecycle. The CRN 2 role monitors participants for adverse events and clinical responses, administers study medications, and ensures high-quality, patient-centered care aligned with protocol requirements. The CRN 2 also educates clinical staff and physicians on study procedures, communicates participant status updates, and supports study implementation within clinical settings. The CRN 2 demonstrates advanced clinical nursing knowledge, growing research expertise, and autonomy in managing protocol activities. Exemplifies the Rush mission, vision and values and acts in accordance with Rush policies and procedures.
Bachelor of Science in Nursing (BSN) OR Master of Science in Nursing (MSN)
Experience: Four years of clinical nursing practice experience required.
Licenses: Current State of Illinois Registered Nurse Licensure
Basic Life Support certification for Healthcare Professionals.
Relevant research certification (Certified Clinical Research Professional (CCRP), Certified Clinical Research Associate (CCRA), Certified Clinical Research Coordinator (CCRC), OR Certified IRB Professional (CIP)) obtained within 1 year of hire

Regulatory Compliance Awareness – Demonstrate knowledge of Good Clinical Practices and/or Good Documentation Practices, human subjects protections, institutional, local, state, and federal guidelines and regulations related to clinical research
Communication Skills – Ability to communicate complex clinical and regulatory concepts in easy-to-understand language
Flexibility – Flexible work hours and travel may be required
Four years of experience in clinical research as appropriate to study population.
Delivers protocol-required nursing care to research participants, including monitoring of health status and documentation.
Develops and modifies participant care plans based on protocol requirements and participant needs.
Communicates study details and updates to participants, families, and interdisciplinary care team members.
Provides in-service training to inpatient and outpatient teams on protocol requirements and participant care.
Notifies the PI and care team of changes in participant health status; Mentors are less experienced research nurses.
Performs complex study-specific procedures, including medication administration, clinical assessments, and sample collection, independently.
Schedules study visits and prepares materials and source documentation for multiple protocols. Reviews and enters data into study systems accurately and on time; Coordinates specimen handling and shipping for multiple protocols; documents findings and participates in resolution planning.
Shares relevant system updates with team members to support quality and compliance.
Applies ALCOA principles to ensure high-quality documentation and data entry across systems; Navigates multiple systems (including REDCap, OnCore, Epic) to manage participant data, schedule visits, and support workflow accuracy.
Identifies and responds to potential issues, protocol deviations or data entry errors; Maintains routine communication with PI and study team regarding visit completion and participant status, including changes in health status.
Communicates study progress and safety issues to PI, study sponsor, and care teams as needed.
Prepares assigned sections of study logs, reports, or summaries to support monitoring and audit readiness.
Captures and verifies visit-related data in CTMS to ensure billing accuracy and collaborates with regulatory or finance staff for corrections as needed.
Serves as a protocol resource for other staff by answering questions and explaining study workflows.
Assists in orienting new research staff or clinical partners to study procedures, tools, or documentation.
Coordinates day-to-day study-related activities with clinical and research staff; May be responsible for budget creation and coverage analysis review
Prepares and submits routine regulatory documents and amendments to the IRB in partnership with regulatory staff; We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.