Research Fellow Phd

Lead Discovery And Optimization Group Research Associate
Top skills: Expertise in mammalian cell culture, experience with plate-based cellular assays, immunoblotting, lentiviral infection, cellular transfection, and basic molecular biology techniques experience preferred.
The Lead Discovery and Optimization Group within Small Molecule Drug Discovery in San Diego focuses on delivering client therapeutics for disease intervention by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly driven Research Associate/Senior Research Associate to assist in the identification and characterization of drug candidates for the treatment of human diseases. The successful candidate will work collaboratively in a multi-disciplinary environment to carry out cell-based and molecular assays in support of small molecule discovery for pre-clinical development.
Responsibilities will include but are not limited to the following:

Design and implementation of high-throughput cell-based reporter assays to characterize drug candidates
Establish stable cell lines via lentiviral transduction and maintain mammalian cell lines
Conduct routine molecular and cellular experiments including DNA/RNA/protein extraction, immunoblot analysis, and immunoprecipitation
Assist senior researchers in executing, conducting analyses, and reporting results of experiments
Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work
Analyze, troubleshoot, and recommend corrective actions for routine problems
Maintain an accurate, comprehensive, and current laboratory notebook
Write protocols, procedures and technical reports
Communicate results via written reports and oral presentations Qualifications:
BS with 2+ years of experience post-graduation or MS. This position is not available to PhD holders
Expertise in mammalian cell culture, plate-based cellular assays, immunoblotting, lentiviral infection, cellular transfection, and basic molecular biology techniques
Experience with medium and high-throughput screening is highly preferred
Experience with targeted protein degradation assay is a plus
Familiarity with automation instruments and multi-mode plate readers
Outstanding problem-solving and organization skills
Effective team player and strong individual contributor
Self-driven, flexible, pragmatic, and able to handle multiple tasks while delivering high quality data
Effective communication skills, both verbal and written