Senior Director, GTM Strategy & Portfolio Planning

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement… read on. In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early‑stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life‑changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you’re someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we’ll ask “why not?” and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical and thoughtful use of AI to improve clarity, speed, and quality of work. Position Summary You are a seasoned rare disease commercialization leader who thrives at the intersection of science, strategy, and execution. You have led—or been a critical architect of—at least one rare disease launch, and you understand that in a small‑patient, high‑science category, every HCP interaction and every patient touchpoint matters. You know how to build a brand from the ground up, how to mobilize a field team around a clear and compelling narrative, and how to make the most of a narrow but deep opportunity. The Senior Director, Head of Marketing will serve as the commercial brand authority for Calci (encaleret)—BridgeBio’s oral CaSR negative allosteric modulator in NDA review for Autosomal Dominant Hypocalcemia Type 1 (ADH1). This is a first‑in‑class asset targeting a chronically underserved rare endocrine population, and this role represents a defining commercial leadership opportunity. You will own the full marketing function for Calci: leading HCP marketing, patient marketing, and KOL engagement under a single integrated brand strategy. You will report directly to the SVP, Sales & Marketing—Endocrinology and will be expected to be on‑site in both our San Francisco and Palo Alto home offices on a weekly basis. This is not a role for someone who needs a playbook. It's a role for someone who writes one. What You’ll Do Brand Strategy & Launch Leadership Own the Calci brand strategy end‑to‑end—positioning, messaging architecture, segmentation, and go‑to‑market sequencing—ensuring full alignment from pre‑NDA approval through Year 1+ commercialization Lead all brand planning milestones, including annual brand plan, launch readiness assessments, and BOD‑level commercial reporting Serve as the senior commercial voice on the Calci Product Team, embedding market realities into cross‑functional planning across Medical Affairs, Regulatory, Market Access, and Patient Advocacy Build and maintain a dynamic competitive intelligence function, monitoring the ADH1 and broader hypoparathyroidism landscape and translating findings into strategic decisions Partner with Value & Access to shape the payer value proposition and ensure access strategies are integrated into brand planning from day one People Leadership & Team Development Directly lead and develop a team of 4, including: Director, HCP Marketing; Director, Patient Marketing; and two KOL Engagement Leads—setting individual performance goals, coaching toward professional growth, and building a cohesive, high‑performing marketing organization Foster a culture of intellectual rigor, creative ambition, and patient‑first accountability across the marketing team Act as the connector between team workstreams, ensuring HCP, patient, and KOL strategies are mutually reinforcing and aligned under one brand narrative Develop the next generation of commercial talent within the team through active mentorship, stretch assignments, and transparent performance management HCP Marketing Oversee the development of a field‑ready HCP promotional platform—including clinical messaging, EAM enablement tools, and channel strategy—built on deep insight into endocrinologist and nephrologist decision‑making Ensure EAM (Endocrine Account Manager) engagement materials reflect the Calci scientific story with precision, clarity, and promotional compliance Lead commercial advisory boards and insight‑generation programs to continuously refine HCP strategy and ensure message resonance Partner with Market Insights to develop HCP segmentation and targeting frameworks, including tiered engagement models for high‑value prescribers Patient Marketing & Disease Awareness Guide the patient marketing director in developing a robust DTC and patient‑facing strategy, with a focus on diagnosis acceleration, disease education, and treatment adherence for ADH1 patients Oversee the commercial patient support ecosystem in partnership with specialty pharmacy and patient services, ensuring a seamless patient journey from identification through persistency Champion familial cascade testing as a patient identification lever, ensuring commercial programs support structured proband communication and relative testing uptake KOL Engagement Provide strategic direction to two KOL Engagement Leads, ensuring a coordinated, insight‑driven KOL plan that spans identification, profiling, advisory board engagement, and speaker bureau development Oversee commercial KOL congress strategy and ensure BridgeBio’s Calci commercial presence at key endocrine and rare disease meetings is impactful and insight‑generating Guide the development and governance of the commercial speaker bureau program in alignment with compliance and legal requirements Forecasting, Analytics & Business Reporting Work with Market Insights to build and pressure‑test launch forecasting models and establish measurable KPIs across all marketing programs Develop and present commercial updates to senior leadership and the Board of Directors, synthesizing brand performance, market dynamics, and strategic pivots Establish a metrics‑driven culture within the marketing team, driving accountability against leading and lagging brand indicators No Matter Your Role at BridgeBio, Successful Team Members Are: Patient Champions, who put patients first and uphold strict ethical standards Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset Truth Seekers, who are detailed, rational, and humble problem solvers Individuals Who Inspire Excellence in themselves and those around them High‑quality executors, who execute against goals and milestones with quality, precision, and speed Where You’ll Work This is a San Francisco/Bay Area based role; joining office‑based collaboration Tuesday through Thursday weekly, is required. Who You Are 12+ years of commercial biotech or pharmaceutical experience, with at least 7 years in pharmaceutical/biotech marketing Prior people management experience required; experience building or scaling a marketing team in a launch setting strongly preferred Rare disease launch experience required—endocrinology or nephrology experience is a significant differentiator Demonstrated success owning brand strategy through launch, including brand planning, promotional development, and commercial execution Proven track record leading KOL engagement programs and commercial advisory board design Experience developing and managing both HCP and patient marketing strategies simultaneously Comfort operating in a pre‑launch, high‑ambiguity environment—able to set direction and drive execution before full commercial infrastructure is in place Strong working knowledge of FDA promotional guidelines, fair balance, and rare disease compliance requirements Exceptional oral, written, and executive presentation skills—incl. comfort with BOD‑level deliverables Ability to travel (~25%) for key congresses, advisory boards, and field engagement Bachelor’s degree required; MBA or advanced science degree preferred Key Attributes Deeply passionate about improving the lives of patients with rare, genetic, and underdiagnosed diseases Visionary brand thinker with the tactical acumen to translate strategy into field‑ready execution Natural leader and talent developer—someone who builds loyalty through clarity, candor, and commitment to team success Collaborative by default, with the spine to advocate for bold commercial decisions when the data and science support it High EQ and self‑awareness; understands the importance of managing up, across, and down with equal skill True entrepreneurial spirit—BridgeBio was built to do things differently and address the needs of underserved populations, driven by science and unrelenting passion for patients Compensation & Benefits At BridgeBio, we strive to provide a market‑competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. The salary range for this role in California is $265,000–$290,000 USD. Financial & Rewards Market‑leading compensation 401(k) with employer match Employee Stock Purchase Program (ESPP) Pre‑tax commuter benefits (transit and parking) Referral bonus for hired candidates Subsidized lunch and parking on in‑office days Health & Well‑Being 100% employer‑paid medical, dental, and vision premiums for you and your dependents Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) Fertility & family‑forming benefits Expanded mental health support (therapy and coaching resources) Hybrid work model with flexibility Flexible, “take‑what‑you‑need” paid time off and company‑paid holidays Comprehensive paid medical and parental leave to care for yourself and your family Skill Development & Career Paths People are part of our growth and success story—from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching We celebrate strong performance with financial rewards, peer‑to‑peer recognition, and growth opportunities #J-18808-Ljbffr BridgeBio Pharma