Scientist 3 - Translational Medicine (Ophthalmology- Glaucoma)

The Position We advance science so that we all have more time with the people we love. Genentech's Translational Medicine OMNI (TM OMNI) Department supports the entire R&D portfolio of novel therapies across Ophthalmology, Metabolism, Neuroscience, Immunology, and Infectious Diseases (OMNI). We develop and implement cutting-edge biomarker strategies to study disease pathways, confirm mechanisms of action, and accelerate clinical trial success. Scientists within our department champion end-to-end biomarker execution, from initial discovery and assay design to data interpretation, while leveraging clinical insights to drive next-generation target discovery. We are seeking a talented and highly motivated Scientist 3 to join Genentech’s Translational Medicine (TM) team on-site at our South San Francisco campus. In this role, you will partner with cross-functional R&D teams to provide critical biomarker support for glaucoma programs throughout the drug development lifecycle, while simultaneously driving insights for next-generation therapeutic targets. This position uniquely bridges data science and the wet lab, requiring a blend of computational skills to interpret high-dimensional datasets and bench-level expertise to design and execute validation experiments. It is a hands‑on, high‑impact opportunity for a scientist eager to apply their training to help establish a new disease area for Genentech and navigate the complexities of ophthalmic drug development within a deeply collaborative environment. As an integral member of our dynamic team, you will: Analyze high-dimensional datasets (e.g., proteomics, transcriptomics) generated from clinical and preclinical samples to discover novel candidate biomarkers and targets. Develop and qualify custom assays (e.g., Simoa, NULISA) for biomarkers of interest, moving beyond standard commercial kits to build bespoke solutions for pipeline programs. Design and execute experiments using disease-relevant in vitro human cell models to translate data-driven insights into functional biology. Lead and coordinate exploratory clinical studies in partnership with internal and external collaborators to discover and qualify translational biomarkers. Collaborate closely with cross-functional R&D partners, including Research Biology, Computational Sciences, Tissue Genomics & Proteomics, Biostatistics, Clinical Pharmacology, and Bioanalytical Sciences. Communicate insights effectively across the organization and the broader scientific community through high-quality reports, presentations, and peer-reviewed publications. Who You Are: A PhD in Biological Sciences (including neuroscience, immunology, retinal biology, or a related field) with 0–4 years of relevant post-graduate experience. Clinical/translational experience, especially in glaucoma and/or retinal diseases is highly desirable. A proven track record of executing both wet lab experiments and bioinformatic analyses, as demonstrated through a strong peer-reviewed publication record. Computational proficiency with hands-on experience programming in R or Python to apply biostatistical and bioinformatics methods to high-dimensional datasets. Deep technical wet-lab expertise in preclinical/clinical sample analysis and molecular biology techniques (including cell culture, ELISA, qPCR, and NGS/transcriptomics). Demonstrated scientific independence, with the proven ability to autonomously formulate biological hypotheses, design robust studies, develop computational analysis plans, and accurately interpret complex results. Outstanding organizational and teamwork skills, including strong time management and a proven ability to thrive in a fast-paced environment. Communication excellence, featuring exceptional oral and written presentation skills, a creative approach to problem-solving, and a clear passion for translating science into life-changing therapies. Relocation benefits are not available for this posting. The expected salary range for this position based on the primary location of California is $100,400 - $186,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this Accommodations for Applicants. #J-18808-Ljbffr Genentech