Scientist II - LNP Formulation (San Diego)

Job Title: Scientist II - LNP Formulation

Location: San Diego, CA | Onsite

Responsibilities

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Qualifications

• Education: Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Master’s degree with 2+ years of industry experience.

Required Skills

• LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.

Preferred Skills

• Preferred Skills: Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.