Lipid Nanoparticle Formulation Senior Scientist to Associate Director (San Diego)

Company Description

We are a privately held, stealth mode start-up biotechnology company developing lipid nanoparticle-based approaches to address unmet medical needs.

The role

We are seeking an experienced hands-on and strategic Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) to establish cutting-edge next-generation LNP platforms focusing on different disease areas. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.

Key responsibilities

• Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations

• Lead formulation innovation efforts, including lipid selection, composition optimization, and novel process development

• Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics

• Lead formulation process scale-up and technology transfer as needed

• Collaborate closely with cross-functional teams (biology, analytics, chemistry, and project management) to advance programs

• Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders

• Contribute to troubleshooting formulation challenges and continuously improve experimental workflows

Professional experience and qualifications

•Senior Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 3-5 years relevant experience;

•Principal Scientist or Associate Director, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 6+ years relevant experience

• Strong hands-on experience with LNP formulations, including formulation development and optimization, process development and scaling-up

• Demonstrated expertise in DOE methodologies and statistical experimental design

• Extensive experience with LNP screening and analytical techniques

• Deep understanding of lipid-based delivery systems and formulation science principles

• Proven ability to work effectively in a team-oriented, fast-paced environment

• Strong problem-solving skills and ability to manage multiple priorities simultaneously

• Strong communication skills for presenting data and influencing technical decisions

What We Offer

• Opportunity to work at the forefront of LNP formulation innovation

• Collaborative, science-driven culture with high impact research

• Competitive compensation and benefits package, including health, dental, vision, and life insurance

• 401(k) with company match