Principal PK/PD Modeling Scientist - Translational Analytics
Amgen Inc
Amgen Inc. (IR) is seeking a Principal Scientist in South San Francisco, CA. This pivotal role contributes to drug discovery by focusing on pharmacokinetics and pharmacodynamics of drug candidates. Responsibilities include applying mathematical modeling and collaborating with cross-functional teams to support drug development decisions. The ideal candidate possesses a Doctorate degree or equivalent experience in quantitative PKPD principles and has proven skills in systems modeling. A comprehensive benefits package and flexible work models are included. #J-18808-Ljbffr Amgen
$163.67k - $221.44k
...Category: Scientific Position Title Principal Scientist‑PKDM, Modeling and Simulation What you will do In... ...response relationships, execution of translational strategies, and influencing... ...fit‑for‑purpose mathematical models (PK‑PD, QSP, PBPK) using specialized relevant...PrincipalFlexible hours- Principal Scientist Computational Biology & Translational AI (Oncology Precision Medicine) Join Amgen's Mission of Serving... ...designing and deploying AI‑enabled analytical and agentic systems that connect... ...literature) using AI‑enabled or model‑based approaches. Strong...PrincipalRemote workFlexible hours
- ...patients while transforming your career. Senior Scientist - Computational Discovery & Translational Analytics What you will do Lets do this. Lets change the world... ...advancements in digital technologies for disease modeling and digital modality engineering to accelerate...SuggestedFlexible hours
$163k - $193k
...while transforming your career. Principal Scientist - Clinical Pharmacology, Modeling & Simulation What you will do... ...and simulation strategies for translational approaches to support clinical... ...Pharmacokinetic/Pharmacodynamic (PK/PD) modeling, Mechanistic-Physiologically...PrincipalRemote workWork from homeFlexible hours$159.6k - $251.2k
Associate Principal Scientist, Respiratory DiscoverySkip to main... ...also uses a Google Analytics Cookie to measure and... ...respiratory biology and translational research to... ...apply human-relevant model systems (e.g., primary... ...stratification, and PK/PD relationships* Experience...PrincipalFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$202.8k - $376.6k
...data and novel computational models to drive impact. Seamless... ...Intelligence (AI) to assist our scientists in both pRED and gRED to... ...Opportunity The AI Biology & Translation (AIBT) department within... ...for biology. As a Senior Principal Scientist, you will lead a team...PrincipalLocal areaWorldwideRelocation package$120k - $140k
Parvus Therapeutics, Inc. in South San Francisco is hiring an Associate Scientist to drive preclinical PK/PD projects and develop models for their clinical pipeline. Candidates should have 6+ years of experience in Immunology (8+ for Bachelor's) and expertise in animal...- ...Job Description Job Description Principal Scientist / Senior Scientist, Analytical Chemistry (Biopolymers) Location: Brisbane, CA (Onsite) About... ...design, formulation, and preclinical science to translate platform innovation into a pipeline of transformative...Principal
$167.4k - $310.8k
...data and novel computational models to drive impact. Seamless... ...Intelligence (AI) to assist our scientists in both pRED and gRED to... ...We are seeking a Senior or Principal Machine Learning Scientist to... ...complex decision‑making. Domain Translation: Translate biological and...PrincipalLocal areaWorldwideRelocation package- Amgen is seeking a Senior Scientist in Computational Discovery & Translational Analytics to advance our mission of serving patients. This role combines expertise in computational biology with state-of-the-art technologies to drive drug discovery through data analysis....
$140k - $250k
Principal Scientist, Protein Sciences, Analytical Characterizations September 2025 Department: Technology Position Summary... ...with a clear orientation toward translating findings to deliver therapeutic... ...novel ‘venture capital-biotech’ model. Our core mission is to...PrincipalFull timeTemporary workFlexible hours$235.5k - $329.5k
...for an experienced Sr. Director of Clinical Pharmacology and Translational PK/PD to lead the technical and operational aspects of the... ...through market authorization Select and execute appropriate modeling and simulation approaches (PK/PD, PopPK, exposure-response)...Full timeWork at officeWork visa3 days per week$202.5k - $236.25k
...seeking a highly motivated and skilled Principal Scientist, Translational Genetics to join our growing team.... ....Develop and apply statistical models to predict disease risk and treatment... ...is strongly preferred.Skills:Strong analytical and problem-solving skills.Excellent...Principal- ...clinical, pharmacological and translational research and development... ...biologyWorks with TM laboratory scientists and academic TLs to address... ...eligible for a hybrid work model with at least 50% onsite at... ...with Ripley.R1600104 : Senior Principal Scientist, Cardiovascular,...PrincipalHourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work
$124.3k - $230.9k
Senior Scientist / Principal Scientist - Synthetic Molecule Analytical Chemistry We are seeking an experienced scientist with a strong record of laboratory innovation... ...strategies. Working knowledge of data analysis, modeling, and AI‑assisted workflows including effective...PrincipalLocal areaRelocation package$159.6k - $251.2k
...and accomplished Associate Principal Scientist to join our Quantitative Biosciences... ...define & execute in vivo model development and pharmacology... ...interpret key findings, and translate complex results into... ...vitro/in vivo correlation, PK/PD, translational biomarker, and...PrincipalFor contractorsShift work- ...transforming your career. Principal Scientist - PKDM (Large Molecule Project... .../pharmacodynamic (PK/PD) properties of biologic therapeutics... ...Designing and executing translational PK/PD and mechanistic ADME... ...time-off plans Flexible work models where possible. Refer to...PrincipalFlexible hours
$141.5k - $262.9k
...that we all have more time with the people we love. The Principal Scientist in Translational Medicine Oncology will support one or more... ...technologies, functional immune assays, and emerging AI-enabled analytical approaches, including agentic AI tools, to uncover mechanisms...PrincipalFull timeLocal areaWorldwideRelocation packageShift work3 days per week$90k - $117k
Denali Therapeutics Inc is seeking a Research Scientist in South San Francisco to leverage animal models for preclinical translational research. The role includes providing in vivo technical support and conducting drug dosing, blood collections, and necropsy procedures...$124.3k - $265.9k
F. Hoffmann-La Roche AG is seeking a Senior Scientist / Principal Scientist specializing in synthetic molecule analytical chemistry in South San Francisco, California. The role involves troubleshooting analytical methods and contributing to regulatory submissions. Ideal...Principal- Amgen SA in South San Francisco seeks a Principal Scientist in Modeling and Simulation. This role will focus on understanding pharmacokinetics and pharmacodynamics, contributing significantly to Amgen's therapeutic modalities. The ideal candidate will hold a PhD and possess...Principal
$177k - $308k
...companies access to drug discovery models trained on years of Lilly's... ...models across key ADMET and PK/PD endpoints — including... ...and designed for partner use. Translational Modeling: Develop translational... ...: Provide coaching to junior scientists and contribute to TuneLab's growing...Full timeFlexible hours- A leading biotech company in California is seeking a Principal Scientist specializing in Computational Biology and Translational AI. This role focuses on integrating multi-modal data to drive forward and reverse translation insights in oncology precision medicine. Ideal...Principal
$268k - $384k
...Senior / Principal ML Scientist, Foundation Models for Life Sciences San Francisco, CA USA Your Impact at LILA Lila is building a platform where... ...experimental results improve model performance Translate complex biological questions into well-defined ML problems...PrincipalFull timeWork at officeLocal areaFlexible hours- AbbVie is seeking a highly motivated scientist for the Quantitative, Translational ADME Sciences (QTAS) department in South San Francisco. The role focuses on developing LC/MS-based bioanalytical methods for novel biological entities, involving data analysis and communication...
$150.7k - $279.9k
...causal disease biology and translate it into actionable targets,... ...Opportunity We are seeking a Principal Scientist (Bioinformatics track) to lead... ...and robust benchmarking) so model outputs are decision‑ready... ...developing and scaling reusable analytics pipelines, platforms, or...PrincipalLocal areaRelocation package$124.3k - $230.9k
Overview We are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory innovation and technical depth to join our Synthetic Molecule Analytical Chemistry (SMAC) group. The successful candidate will thrive at the bench and...PrincipalLocal areaRelocation package$124.3k - $230.9k
...are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of... ...depth to join our Synthetic Molecule Analytical Chemistry (SMAC) group. This role is... ...Working knowledge of data analysis, modeling, and AI‑assisted workflows, including...PrincipalLocal areaRelocation package- ...ML Research Scientist, Foundation Models About the Team Join a world-class team at the forefront... ...of seniority: Senior, Staff, and Principal. You will Lead transformative... ...with a multidisciplinary team to translate your research into tangible impact on...PrincipalTemporary work
$159.6k - $251.2k
...We are seeking an Associate Principal Scientist with strong expertise in respiratory biology and translational research to contribute to target... ...and apply human-relevant model systems (e.g., primary airway... ...patient stratification, and PK/PD relationships Experience in...PrincipalFull timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work
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