DTE Audit & Compliance Manager (Sr. Principal Analyst)

Vertex Pharmaceuticals seeks an experienced Audit & Compliance Manager to oversee audit, inspection, and compliance activities for Data, Technology & Engineering. This Sr. Principal Analyst role coordinates GxP audits, regulatory inspections, and remediation efforts while serving as liaison between operational teams and auditors in a complex, matrixed organization.

Responsibilities

• Serve as primary DTE liaison for IT audit, inspection, and compliance requests across GxP and regulatory activities
• Coordinate audit preparation, evidence collection, stakeholder readiness, and response tracking with business teams and auditors
• Track audit findings, CAPAs, and remediation commitments through closure and escalate at-risk deadlines
• Oversee compliance metrics dashboard, analyze audit trends, and provide readiness and status reporting to leadership
• Drive remediation meetings, promote consistent audit practices across DTE, and identify process improvement opportunities

Requirements

• 5–8+ years in IT Compliance, Quality, Internal Audit, SOX, or GxP Compliance
• Experience supporting audits, inspections, and remediation in regulated environments
• Knowledge of GxP, CSV/CSA, 21 CFR Part 11, SOX, NIST SP 800-53, GDPR, and audit methodologies
• Experience overseeing contractors and managed service provider operations
• Demonstrated ability to develop and lead remediation or risk mitigation strategies
• Strong project management skills in matrixed organizations with cross-functional influence
• Knowledge of application/system development methodologies and IT Service Management practices

Compensation: $164,400 - $246,600 base