Director, CGT Technology

Job Description Director, Business Engagement & Technology – Commercial Cell and Gene Therapy Location: Hybrid or On-site Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. We focus on specialty markets where we have deep expertise in science, technology, and patient needs. At Vertex, our Data, Technology & Engineering (DTE) organization plays a critical role in accelerating business performance, enabling digital and AI transformation, and delivering scalable platforms that support innovation across the enterprise. Role Summary The Director of Business Engagement & Technology will serve as the strategic technology leader supporting the Commercial CGT business unit. This role is responsible for shaping and executing the data, technology, and AI roadmap that enables the business to scale global operations effectively. This leader will act as the primary DTE partner, ensuring strong alignment between business priorities and technology strategy. The role will drive portfolio planning, oversee project execution, and partner across teams to deliver business value through modern, scalable, and compliant technology solutions. Key Responsibilities • Serve as a strategic technology partner for the Commercial Cell and Gene Therapy business unit. • Define and lead the data, technology, and AI roadmap to support business growth and global operational scale. • Act as the primary liaison and trusted advisor between the business and DTE. • Shape, prioritize, and manage the project portfolio to align with strategic business goals and enterprise technology priorities. • Oversee large project execution, ensuring delivery against scope, timeline, budget, and expectations • Translate business strategies and operational needs into actionable technology initiatives and solution roadmaps. • Partner with cross-functional stakeholders across DTE, Commercial, Supply Chain, Quality and others • Identify opportunities to leverage data, digital platforms, and AI capabilities to improve decision-making, efficiency, and business outcomes. • Drive governance, planning, and communication processes for technology investments and program delivery. • Ensure solutions are scalable, secure, compliant, and aligned with enterprise architecture standards. • Monitor evolving business needs, industry trends, and emerging technologies to continuously enhance the technology strategy. • Build strong stakeholder relationships and influence decision-making at senior leadership levels. Required Qualifications • Bachelor’s degree in Information Technology, Computer Science, Engineering, Business, or a related field; advanced degree preferred. • Significant leadership experience in business engagement, technology strategy, digital transformation, or related roles. • Demonstrated experience partnering with business leaders to define and deliver technology roadmaps tied to strategic outcomes. • Proven success managing complex project portfolios and leading cross-functional technology initiatives. • Experience overseeing project execution in a matrixed, global organization. • Strong understanding of data, enterprise technology platforms, and AI-enabled business solutions. • Ability to bridge business strategy and technical execution with strong communication and influencing skills. • Experience serving as a primary business partner or relationship manager for technology functions. • Strong organizational, prioritization, and decision-making skills. • Ability to operate effectively in a fast-paced, highly collaborative environment. Technical Skills Required • Technology roadmap development • Data strategy and enablement • AI and advanced analytics strategy • Project portfolio management • Program and project execution oversight • Business relationship management • Digital transformation leadership • Cross-functional stakeholder management • Enterprise technology planning • Governance and prioritization frameworks • Scalable global operations support • Technology-business alignment • Budget management Preferred Skills • Experience supporting Commercial, Cell and Gene Therapy, or Hematology-focused business functions. • Commercial technology and GxP system expertise, including experience with platforms such as Salesforce • Familiarity with regulated industry environments such as biotechnology, pharmaceuticals, or healthcare. • Experience with global technology deployments and change management. • Strong understanding of enterprise data ecosystems, reporting, and analytics capabilities. • Ability to identify and implement innovative digital and AI solutions that improve commercial effectiveness. • Experience working within a Data, Technology & Engineering or similar enterprise technology function. • Executive presence with the ability to communicate strategy, risks, and progress to senior stakeholders. Benefits Vertex offers a competitive and comprehensive rewards package designed to support employees’ well-being, growth, and success. Benefits may include: • Competitive base salary and incentive compensation • Comprehensive medical, dental, and vision coverage • Retirement savings programs • Paid time off and company holidays • Professional development and learning opportunities • Wellness and employee assistance programs • Inclusive and collaborative work environment • Opportunities to contribute to transformative work that impacts patients globally Pay Range: $198,000 - $297,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.