Postdoctoral Fellow

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! POSTDOCTORAL FELLOW - NEUROLOGY RESEARCH SUMMARY: We are seeking a highly motivated and exceptional scientist to join our Neurology Research group as a Postdoctoral Fellow investigating the cellular and molecular mechanisms underlying white matter injury and repair. The successful candidate will develop and apply innovative cellular and animal models to identify and validate therapeutic targets that promote oligodendrocyte maturation and remyelination. This position offers an exciting opportunity to conduct innovative research in a multidisciplinary RNA therapeutics environment and contribute to the development of novel therapies for neurological disorders. WORK LOCATION: Onsite Carlsbad RESPONSIBILITIES: Design and execute innovative research to investigate mechanisms underlying white matter injury and repair. Develop and apply cellular and animal models to study disease biology and evaluate therapeutic hypotheses. Employ molecular, cellular, imaging, and OMICS approaches to identify and validate novel therapeutic targets. Analyze, interpret, and communicate experimental findings to multidisciplinary project teams. Publish research in peer-reviewed journals and present findings at internal and external scientific meetings. REQUIREMENTS: A Ph.D. in Neurobiology, Cell Biology, or a related discipline with a strong publication record in peer-reviewed journals. Research experience in oligodendrocyte biology, myelination, developmental neuroscience, or related neurobiology is highly desirable. Experience with human iPSC culture and differentiation, primary neural cell cultures, or advanced in vitro models is preferred. Experience with transcriptomic and translational profiling, single-cell RNA sequencing, or other OMICS approaches is advantageous. Experience with molecular biology techniques including qPCR, RNA analysis, immunocytochemistry/immunohistochemistry and fluorescence/confocal microscopy is advantageous. Experience with rodent models, tissue processing, and histological analyses is beneficial. Strong organizational, communication, and problem-solving skills with the ability to work independently and collaboratively in a multidisciplinary environment. Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: The pay scale for this position is $65,000 to $87,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. #J-18808-Ljbffr