Bioinformatics Scientist

Job Family: Scientist Travel Required: None Clearance Required: Ability to Obtain Public Trust What You Will Do: We are looking for a Bioinformatics Scientist (Scientist V) in the IBIS Core to support the Vaccine Research Center (VRC) at NIAID through advanced computational biology and bioinformatics analysis. This position is a full-time position located in Bethesda, MD. Implement and utilize workflows for next generation sequencing (NGS), including quality control (QC) and data analysis. Initiate interdisciplinary collaborations with scientists from other organizations or institutions engaged in related research. Provide scientific mentorship and guidance to students, postdoctoral fellows, technicians, and other staff in developing bioinformatics pipelines, particularly for spatial transcriptomics applications. Provide programming and troubleshooting support to the Federal Government in the dissemination of research data. Perform computational analysis of research datasets and identify trends and patterns. Collaborate with multidisciplinary teams to design, analyze, manage, and interpret complex biological data. Maintain detailed documentation of analyses and present results at laboratory meetings. Develop novel computational programs and algorithms to facilitate discovery in large and complex datasets. Evaluate and adapt bioinformatics techniques based on scientific literature, available resources, and research objectives. Collaborate with experimentalists and computational scientists to develop new computational tools for scientific discovery. Independently coordinate training of personnel on scientific, statistical, and programmatic software applications. Present research findings at internal meetings, conferences, and seminars; contribute to scientific publications. Attend scientific and programming meetings and maintain organized records of findings and discussions. What You Will Need: Master’s Degree in Bioinformatics, Computational Biology, or a related discipline. A minimum of TWO (2) years of experience working with large, multimodal single-cell datasets. Proficiency in Python and R programming languages. Practical knowledge of and experience working with SLURM-managed high-performance computing (HPC) clusters. Strong analytical, statistical, and problem-solving skills. Experience with next generation sequencing (NGS) workflows and data analysis. Ability to collaborate effectively in a multidisciplinary research environment. Strong written and verbal communication skills, including presentation of scientific data. Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred. What Would Be Nice To Have: Ph.D. in Bioinformatics, Computational Biology, or a related discipline preferred. Experience with Xenium and/or Visium spatial transcriptomics platforms is preferred. Familiarity with adaptive immune receptor repertoires and general immunology are beneficial. The annual salary range for this position is $65,000.00-$108,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs. What We Offer: Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace. Benefits include: Medical, Rx, Dental & Vision Insurance Personal and Family Sick Time & Company Paid Holidays Parental Leave 401(k) Retirement Plan Group Term Life and Travel Assistance Voluntary Life and AD&D Insurance Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts Transit and Parking Commuter Benefits Short-Term & Long-Term Disability Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities Employee Referral Program Corporate Sponsored Events & Community Outreach Care.com annual membership Employee Assistance Program Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.) Position may be eligible for a discretionary variable incentive bonus About Guidehouse Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. 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Guidehouse is a global AI-led professional services firm delivering advisory, technology, and managed services to the commercial and government sectors. With an integrated business technology approach, Guidehouse drives efficiency and resilience in the healthcare, financial services, energy, infrastructure, and national security markets. Built to help clients across industries outwit complexity, the firm brings together approximately 18,000 professionals to achieve lasting impact and shape a meaningful future. guidehouse.com