Chemical Biologist

## Chemical BiologistApplylocations: US - MD, Bethesdatime type: Full timeposted on: Posted Todayjob requisition id: 40260**Job Family:**Scientist**Travel Required:**None**Clearance Required:**Ability to Obtain Public Trust**What You Will Do:** We are currently searching for a Chemical Biologist to provide support services to satisfy the overall operational objectives of the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD.* Synthesize and optimize small cyclic peptides for diagnostic imaging and early-stage drug discovery applications.* Design and develop small molecules as chemical tools to support biological research, including target validation and imaging (MRI, optical, PET).* Develop and implement mRNA-based peptide expression systems for cyclic peptide production.* Perform peptide conjugation, including linking to fluorescent dyes, chelators, or imaging agents.* Prepare and characterize antibody fragments (e.g., nanobodies, Fab2) and conjugate them for imaging applications.* Conduct compound screening, synthesis, and optimization workflows.* Utilize modern analytical instrumentation to characterize compounds and ensure quality.* Collaborate closely with multidisciplinary teams in a service-oriented research environment.* Document and communicate experimental results effectively through reports and presentations.**What You Will Need:*** Ph.D. in Chemistry, Biochemistry, or related field with a minimum of TWO (2) years of laboratory research experience OR Master's degree in Chemistry, Biochemistry, or related field with a minimum of FOUR (4) years of laboratory research in lieu of Ph.D.* Demonstrated expertise in cyclic peptide generation, screening, synthesis, and optimization.* Strong background in synthetic chemistry, including small molecule and peptide synthesis.* Knowledge of chemical biology approaches for drug discovery or imaging applications.* Experience with or knowledge of fluorescent dyes, chelators for radioactive metals, MRI agents and nanoparticles.* Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.**What Would Be Nice To Have:*** Ability to design and execute complex experiments independently.* Excellent communication skills.* Proven ability to work effectively in a collaborative, team-based environment.The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.**What We Offer:**Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.Benefits include:* Medical, Rx, Dental & Vision Insurance* Personal and Family Sick Time & Company Paid Holidays* Parental Leave* 401(k) Retirement Plan* Group Term Life and Travel Assistance* Voluntary Life and AD&D Insurance* Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts* Transit and Parking Commuter Benefits* Short-Term & Long-Term Disability* Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities* Employee Referral Program* Corporate Sponsored Events & Community Outreach* Care.com annual membership* Employee Assistance Program* Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)* Position may be eligible for a discretionary variable incentive bonus #J-18808-Ljbffr