Senior Manager, IT Operations
$143.1k - $200kMerck & Co. Inc
Senior Manager, IT Operations – Global IT Operations Repligen is seeking a Senior Manager, IT Operations to lead global Tier 2 and platform operations across a multi‑site environment supporting manufacturing, laboratory (OT), and corporate functions. This leadership role owns service stability, operational performance, and user experience across a rapidly growing global footprint. What You’ll Do Lead and develop a global IT operations team, driving accountability, performance, and service excellence. Own service delivery performance, including MTTR, SLAs, backlog, and end‑user satisfaction. Establish and enforce a clear Tier 1 / Tier 2 / Tier 3 operating model. Lead major incident management and drive timely resolution and root‑cause analysis. Mature and enforce ITIL processes (incident, problem, and change management) using ServiceNow. Define and track operational KPIs and reporting to provide visibility into service performance. Oversee hybrid structure operations across Azure and on‑prem environments. Manage identity services across Active Directory and Microsoft Entra ID. Lead endpoint and device management strategy, including Intune, SCCM, and Autopilot. Ensure enterprise patching, endpoint compliance, and secure configuration management. Manage vendors, managed service providers, and third‑party partners, including SLAs and performance. Contribute to IT operations budgeting, cost control, and resource planning. Own disaster recovery, business continuity readiness, and capacity planning across global environments. Partner with manufacturing, laboratory (OT), and cross‑functional IT teams to drive reliability, standardization, and continuous improvement. What We’re Looking For 12+ years of IT experience, including 5+ years leading infrastructure or operations teams. Proven ability to build, develop, and elevate global technical teams. Strong hands‑on experience with Microsoft Entra ID and Active Directory. Azure and hybrid infrastructure (AWS experience a plus). Endpoint management (Intune; SCCM a plus). Enterprise patching, compliance, and device lifecycle management. Microsoft 365 ecosystem knowledge. Experience with ITSM tools and frameworks (ServiceNow required; ITIL strongly preferred). Demonstrated ability to improve operational performance through KPIs, SLAs, and process maturity. Experience managing vendors and third‑party service providers. Understanding of structure operations in regulated or manufacturing environments. Experience with disaster recovery, business continuity, and capacity planning. Strong leadership, communication, and stakeholder management skills. Operational mindset with a focus on reliability, scalability, and continuous improvement. Experience building and scaling high‑performing global teams, driving capability growth while fostering a collaborative, service‑oriented culture. Microsoft certifications are a strong plus. Salary & Benefits The estimated base salary range for this role, based in the United States of America, is $143,100–$200,000. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location, internal equity, and alignment with market data. Employees are eligible to participate in variable cash programs (bonus or commission) and may receive equity as part of the compensation package. Benefits include paid time off, health/dental/vision, retirement benefits, and flexible spending accounts. #J-18808-Ljbffr
$171.78k - $190.34k
...drug undruggable targets and improve patient outcomes. For more information, please visit Job Summary As C4T's Senior Manager, IT Operations, you will oversee the day-to-day operation of our business-critical applications and IT infrastructure (both cloud and on...Senior$143.1k - $200k
...What You’ll Do Lead and develop a global IT operations team, driving accountability, performance, and service excellence. Own service delivery... ...1 / Tier 2 / Tier 3 operating model. Lead major incident management and drive timely resolution and root cause analysis. Mature...SeniorFlexible hours- ...Role Overview & Key Functions: Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the...SeniorLocal area
$175k - $213k
...Senior Manager, Cyber Security Operations Ardelyx is a commercial-stage biopharmaceutical company focused on redefining treatment approaches for patients... ...service provider (MSP) model to an internally operated IT and security organization, this individual will help...SeniorFull timeWork at officeFlexible hours$139k - $187k
...in Boston is seeking an End User Services Senior Manager to oversee the full end user services portfolio, ensuring responsive operations and governance across all Wave locations. The... ...will have 10+ years of experience in IT operations, strong vendor management, and strategic...Senior- ...Energy Jobline ZR is seeking a Manager, Project & Process in Watertown, Massachusetts. This role involves leading cross-functional teams and managing various project lifecycle stages, with a focus on project delivery and process optimization. The ideal candidate will have...Senior
- ...fostering our culture of empowerment. Position Overview The Senior Manager, Cybersecurity Operations, serves as a key leader responsible for directing the... ...technologies. Engage and lead teams across the entire IT, OT, and managed services landscapes, ensuring seamless...SeniorContract workLocal areaRemote work
- ...LifeMine Therapeutics is looking for an experienced Manager/Sr Manager in Clinical Operations in Watertown, Massachusetts. You will lead the planning, execution, and management of clinical trials, ensuring they meet both timelines and regulatory requirements. The successful...Senior
$71.3k - $117k
...ASM Research, An Accenture Federal Services Company, seeks an Operations Manager for DDLC Support in Boston, MA. This role leads delivery operations... ...Ideal candidates have at least 8 years of experience managing IT or operations projects and a Bachelor's degree in a related...SeniorContract work$209.2k - $261.52k
...Innovation - TRUE Innovation! Position Summary: The Senior Director, IT Infrastructure and Operations will lead IT infrastructure, operations, and key... ...devices, IT applications, networks, and the service desk. Manage configurations, software installs, updates, and...SeniorFull timeContract work$71.3k - $124.5k
...Mass Digital Health is seeking a Senior Project & Program Manager to guide projects through the customer onboarding and post-sales lifecycle effectively. The role offers a hybrid work model where you will spend eight days a month onsite within 50 miles of your residence...SeniorRemote work- ...Odyssey Systems Consulting Group, Ltd. is looking for a Program Manager to support the U.S. Air Force’s SAP IT efforts at Hanscom AFB. The role involves providing A&A expertise, managing complex technical initiatives, and supporting acquisition documentation. The ideal...Senior
- ...Pure Resourcing Solutions in Cambridge is looking for an experienced IT Manager to lead day-to-day operations and manage complex infrastructure. The role combines strategic leadership with hands-on responsibilities across a multi-site environment. The ideal candidate...Senior
$160k - $180k
...TScan is looking for an experienced Quality Assurance (QA) professional to join our team as QA Operations Manager supporting our internal GMP Cell therapy manufacturing. This position will be based in our cGMP Manufacturing site in Waltham, MA, and will directly support...SeniorLocal area$71.3k - $124.5k
...Senior Project & Program Manager (Sales Lifecycle - Software) Responsible for guiding assigned projects through the customer onboarding and post‑sales lifecycle to successful close. Operates with limited direction, exercising significant autonomy in determining objectives...SeniorWork at officeRemote work- ...Odyssey in Lincoln, MA is seeking a Program Manager to support the U.S. Air Force’s Special Access Program IT efforts at Hanscom AFB. The role requires strong acquisition knowledge and expertise in managing complex technical initiatives for high-priority programs. The...SeniorRemote work
$99k - $232k
...A leading consulting firm is seeking an Operations Consulting Manager to supervise teams and manage client solutions. The ideal candidate will possess at least 6 years of relevant experience and a Bachelor's Degree in Accounting or Business. Responsibilities include developing...Senior- ...MIT Lincoln Laboratory in Lexington, MA, is looking for a Senior IT Project Manager to lead complex cross-functional programs. This role is pivotal for transforming organizational capabilities through enterprise platforms, data initiatives, and infrastructure modernization...Senior
- ...LifeMine Therapeutics is seeking an experienced and results-driven Manager/Sr Manager, Clinical Operations to join our growing Clinical Development team. Reporting to the Director of Clinical Operations, this individual will play a key role in the planning, execution,...SeniorContract work
- ...The RMR Group LLC is seeking a Property Manager for their Newton, MA location. The role involves managing approximately 735,283 sq. ft. of property, ensuring that operations run smoothly, adhering to established procedures while building strong tenant relations. The ideal...Senior
$104k - $145.33k
...The Broad IT Services (BITS) group believes exceptional people produce exceptional products... ...expert (SME) for AV technology and a manager of the AV team. In partnership with our... ...Desk team, the AV Team leads front-line operations and support of AV, working hand-in-hand with...SeniorFor contractorsWork at officeLocal areaFlexible hours$136.2k - $204.2k
...We are seeking an experienced and dynamic Senior Enterprise IT Program Manager to drive and lead highly complex, enterprise-wide business and technology... ...the full program ecosystem, ensuring all workstreams operate as a single, aligned program where progress translates into...SeniorLocal area$55 per hour
...THE PANTHER GROUP is seeking a Senior Travel & Expense Operations Specialist for a hybrid opportunity in Boston, MA. The ideal candidate will have extensive experience in SAP Concur and managing complex travel operations. This role involves system administration, user...SeniorHourly payPermanent employment- ...BlueRock Therapeutics is seeking a Senior Manager, Systems and Metrics, in Cambridge, MA, to manage and support systems integral to Clinical Operations. This role requires expertise in the pharmaceutical industry, focusing on system processes and data quality. The ideal...Senior
$115k - $170k
...Vanasse Hangen Brustlin, Inc. is seeking a Project Manager for their Massachusetts Highway and Structures Team to oversee complex transportation projects across New England. This role requires strong leadership in project execution and collaboration with multidisciplinary...SeniorLocal areaFlexible hours- Mass General Brigham Community Physicians is seeking a Senior Project Operations Associate to support key operational and data-driven initiatives... ...and collaboration, requiring 5-7 years of project management experience in healthcare. The candidate will manage multiple...Senior
$120k - $202.5k
...STATE STREET CORPORATION is seeking a Tech Operations Governance Lead to oversee technology services in Investment Management. This senior role demands expertise in asset management technology, governance discipline, and the ability to influence across a global organization...Senior$161.7k - $338.5k
...environments. The Data Center Infrastructure Operations / Facilities team plays a critical role... ...worldwide. Role Overview As Senior Director, Operations, you own day-to-day... ...operational organizations. • Proven ability to manage crises, scale teams, and maintain...SeniorTemporary workWorldwideFlexible hours$144k - $191k
...is powered by Lattice OS, an AI-powered operating system that turns thousands of data streams... ...and estimation, and experience managing complex projects with multiple sub-teams... ...receive an email from one of our recruiters, it will only come from an @anduril.com address...SeniorFull timeWork experience placementImmediate start$245.99k - $303.87k
...objectives. Serve as CMC executive lead on the AKB-097 program team and represent Technical Operations in cross‑functional decisions. Establish external manufacturing and lifecycle management strategies for global commercialization. Oversee drug substance/drug product process...Senior
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