Principal Scientist, Translational Genetics

Cytokinetics seeks a Principal Scientist in Translational Genetics to analyze large-scale genomic datasets and identify therapeutic targets for cardiovascular and muscle diseases. The role combines statistical genetics, bioinformatics, and AI/ML methods to translate genetic insights into clinical applications.

Responsibilities

• Perform GWAS, fine-mapping, and statistical genetics analyses on large-scale genomic datasets
• Analyze and integrate multi-omics data to identify causal variants and disease-associated pathways
• Identify and prioritize genetic targets for therapeutic intervention based on statistical evidence
• Develop bioinformatics pipelines for genomic and electronic health records data processing
• Collaborate with cross-functional teams and present findings at conferences and in publications

Requirements

• Ph.D. in Statistical Genetics, Human Genetics, Bioinformatics, or Computational Biology
• 6+ years biotech or pharmaceutical industry experience with demonstrated project impact
• Expertise in GWAS, sequencing data analysis, and large-scale genomic dataset interpretation
• Proficiency in R, Python, and bioinformatics tools including PLINK and Hail
• Strong analytical and problem-solving skills with excellent communication abilities
• Prior cardiovascular or cardiometabolic therapeutic domain experience strongly preferred
• Mendelian randomization and multi-omics data integration experience highly desirable

Compensation: $202,500-$236,250 base per year