Sr. Downstream Processing Technician

Job Description

Job Description

Downstream Processing Technician III

Job Description

The Downstream Processing Technician III supports large-scale biologics and pharmaceutical manufacturing by executing downstream processing activities in a cGMP-regulated cleanroom environment. This role focuses on flawless execution of manufacturing batch records, work instructions, and SOPs, while maintaining rigorous documentation, safety, and quality standards. The technician collaborates closely with a team of scientific and manufacturing professionals to produce biologics used in pharmaceutical products, contributing directly to therapies such as those for autoimmune diseases.

Responsibilities

• Execute manufacturing batch records, work instructions, and SOPs with a proactive focus on achieving right-first-time performance.
• Assist with batch record reconciliation to ensure accuracy and completeness of production documentation.
• Support all departmental functions, including maintaining suites, supplies, equipment, logbooks, and data in accordance with site SOPs and policies.
• Document all activities in compliance with cGMP requirements, including daily record reviews, task tracking, and database entries.
• Complete document reviews and revisions to maintain current and compliant procedures and records.
• Actively provide feedback on documentation, processes, and workflows to drive continuous improvement.
• Participate in and, when needed, lead shift exchanges, one-on-one discussions, and team meetings to facilitate communication and address changing area needs, including lean activities.
• Support quality investigations by answering questions, providing detailed feedback, and suggesting practical process improvements.
• Practice and promote safe work habits, strictly adhering to safety procedures and guidelines at all times.
• Critically evaluate processes with foresight, identifying potential issues and opportunities for optimization before they arise.
• Prioritize tasks effectively by interpreting production schedules and aligning work execution with manufacturing timelines.
• Apply aseptic techniques and cleanroom best practices while working in aseptic suites.
• Handle and operate laboratory and downstream processing equipment in accordance with established procedures.
• Contribute subject matter expertise in downstream processing steps, where applicable, to support process development and troubleshooting.

Essential Skills

• Minimum of 2 years of work experience in manufacturing, operations, production, laboratory, or a related setting.
• Bachelor’s degree (BS) in a STEM-related field.
• Ability to execute and follow detailed manufacturing batch records, work instructions, and SOPs accurately.
• Strong attention to detail with a focus on right-first-time execution.
• Ability to maintain accurate, complete, and compliant documentation in a cGMP-regulated environment.
• Understanding of or exposure to cGMP practices, aseptic techniques, or chemical concepts.
• Capability to work effectively in a cleanroom or aseptic suite, including following strict gowning and behavior requirements.
• Ability to interpret production schedules and prioritize tasks accordingly.
• Strong communication skills to participate in shift exchanges, one-on-one meetings, and team discussions.
• Commitment to safe work habits and adherence to safety procedures and guidelines.
• Physical ability to lift a minimum of 25 lbs independently and stand for approximately 80% of the shift.

Work Environment

This role operates in a cleanroom and aseptic suite environment that requires strict adherence to gowning and contamination control procedures. Team members must be willing and able to wear full gowning, including a bodysuit, gloves, hair and beard nets, face covers, safety glasses, and other protective garments such as Tyvek, nitrile, and/or latex gloves. Certain personal items and products, such as makeup, jewelry, nail polish, cologne or perfume, and scented lotions or hair care products, are not permitted in the cleanroom. The position requires the ability to lift at least 25 lbs independently and to stand for approximately 80% of the shift. Initial training typically follows a Monday–Friday schedule for 4–6 weeks from 8:00 a.m. to 4:30 p.m. After training, the role transitions to a 2nd shift schedule from 1:00 p.m. to 11:30 p.m. with a rotating two-week pattern: Week 1 includes days off on Sunday, Thursday, and Friday, with workdays on Monday, Tuesday, Wednesday, and Saturday; Week 2 includes workdays on Sunday, Wednesday, Thursday, and Friday, with days off on Monday, Tuesday, and Saturday. The environment is highly collaborative and quality-focused, supporting large-scale biological and chemistry-based pharmaceutical operations that produce proteins and other biologics used in pharmaceutical products.

RECENT GRADS CAN APPLY!!!

This is a Contract to Hire position based out of Saint Louis, MO.

The pay range for this position is $30.80 - $30.80/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

This is a fully onsite position in Saint Louis,MO.

This position is anticipated to close on Jun 22, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email View email address on ziprecruiter.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.