Scientist

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is seeking a Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Cancer Institute (NCI) located in Bethesda, MD. Benefits We Offer: Paid Time Off and Paid Holidays 401K match up to 5% Educational Benefits for Career Growth Employee Referral Bonus Flexible Spending Accounts: Healthcare (FSA) Parking Reimbursement Account (PRK) Dependent Care Assistant Program (DCAP) Transportation Reimbursement Account (TRN) Position Overview Contractor will independently provide support services to satisfy the overall operational objectives of the National Cancer Institute, Center for Cancer Research. The primary objective is to provide services and deliverables through performance of support services. Requires a Master's degree; a Ph.D. in Biology, Life Sciences, or a related discipline is required, along with a minimum of 2 years of experience in a laboratory environment. Additional Qualifications Certifications & Licenses Ph.D. in Biology, Life Sciences or related discipline Field of Study PowerPoint Microsoft Office Suite MS Word Excel Software PowerPoint Microsoft Office Suite MS Word Excel Skills Minimum of 2 years' experience in a laboratory environment Research experience in immunology and/or molecular biology Expertise in mouse handling procedures, including intraperitoneal/intravenous injections, tumor measurements, and dissections; immunologic studies including multi-parameter flow cytometric processing and data analysis, as well as in‑vitro functional assays including cell culture, stimulation, proliferation, and cytokine production Expertise in molecular studies techniques including DNA/RNA extraction and quantification, gel electrophoresis, western blotting, PCR, and immunoprecipitation; helpful (though optional) experience in other techniques such as confocal microscopy Ability to learn new techniques and teach known techniques to others Knowledge of proper laboratory techniques, disposal methods, laboratory safety procedures, and universal precautions Ability to work independently on projects Excellent analytical, organizational, interpersonal, and time management skills Strong communication skills, both oral and written Proficiency in the use of computers and computer programs, including expertise in Microsoft Office Suite (MS Word, PowerPoint, Excel) Work documents and products related to working with laboratory personnel in designing and performing experiments, data analysis and interpretation of results — Ad-Hoc Work documents and products related to initiating, designing, and developing new projects or assays that can enable the Center for Cancer Research/Rare Tumor Initiative, Dr. U. Rudloff's Laboratory to fulfill its responsibilities for advancing cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines — Ad-Hoc Work products and documents related to performing studies that result in technical reports and information to advance cancer research — Ad-Hoc Work products and documents related to working with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of the impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment — Ad-Hoc Statement of Work Details Conduct laboratory-based translational research with a focus on drug development for the treatment of cancer — 1 Study cultured human and animal cell lines, some of which may be derived from cancer tissue, and analyze human and/or animal tissues with and without cancer — 2 Perform a wide range of sophisticated genetic, biological, and biochemical assays, including, but not limited to, DNA transfection of cells, monolayer and anchorage-independent growth assays, immuno-precipitation assays, agarose gel electrophoresis, and in vivo and in vitro kinase assays — 3 Perform confocal immune-confocal microscopy of cells — 4 Supports the planning and execution of research experiments in the context of the laboratory's overall research program Perform studies that result in technical reports and information to advance cancer research Initiate, design, and develop new projects or assays that can enable the Center for Cancer Research/Laboratory of U. Rudloff, Rare Tumor Initiative, POB, NCI to fulfill its responsibilities for advancing cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines Serve as an authority on the tumor biology being studied and the assays being performed Interpret results of initial analysis to reveal conclusions and shortcomings; identify pitfalls in the original choice of methods or experimental direction; redirect the study to achieve improved results Identify the need for further investigations and/or propose a change in direction of work in light of accomplishments, findings, and current and future mission objectives Supports laboratory staff on research projects and techniques Work with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of the impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment Collaborate with scientists and statisticians in NCI, NIH, and extramural research institutions as appropriate, to advance the research projects and elucidation of cancer-related data Collaborate with NIH/NCI expert staff to clarify needs and project objectives Maintains laboratory equipment and the training of others in their use Assists in maintaining adequate space and facilities for ongoing and projected research studies Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts Attend seminars within the National Institutes of Health/Center for Cancer Research/Laboratory of U. Rudloff; pursue additional training where necessary; participate in discussions at meetings Make oral presentations at various conferences and seminars Prepare data sets, tables and figures for collaborative papers prepared for publication in peer-reviewed journals; assemble and write papers for first-author publication in peer-reviewed papers Participate in special committees, panels, and colloquia that meet to determine policy or plan activity in the field Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed. The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate. Accessibility: If you need an accommodation as part of the employment process please contact: View email address on click.appcast.io This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location. Salary Range

$80,000 - $87,000 USD