Pediatrics - Neurology NRI (Instructor)

Summary

We are seeking a highly motivated and innovative Gene Editing Scientist to join a multidisciplinary team focused on developing cutting-edge human models of disease and advancing translational applications in neurodevelopmental and neurodegenerative disorders. The successful candidate will lead and execute genome engineering strategies across a range of platforms, including human induced pluripotent stem cells (iPSCs), 2D human brain models, and organoids. This position offers a unique opportunity to contribute to transformative discoveries at the intersection of gene editing and human disease modeling.

Job Duties

• Design, develop, and optimize genome editing strategies using CRISPR/Cas systems (e.g., CRISPR-Cas9, base editing, prime editing)
• Generate and validate genetically modified cell lines, including iPSCs and differentiated neural cell types
• Perform clonal selection, screening, and molecular validation (PCR, sequencing, off-target analysis)
• Collaborate with cross-functional teams (genetics, bioinformatics, cell biology, electrophysiology) to integrate multi-omics and functional data
• Maintain detailed experimental records and contribute to publications, grant applications, and presentations
• Stay current with emerging genome editing technologies and implement innovative approaches
• Ensure compliance with institutional biosafety and regulatory guidelines

Minimum Qualifications

• Ph.D. in Molecular Biology, Genetics, Neuroscience, Bioengineering, or related
• field
• 3+ years of hands-on experience in genome editing, particularly CRISPR-based
• approaches
• Demonstrated expertise in mammalian cell culture, including stem cells (iPSCs
• preferred)
• Experience with cloning, vector design, and delivery systems (viral and non-viral)
• Strong background in molecular biology techniques (PCR, qPCR, NGS, Western
• blotting)
• Experience with clonal isolation and validation of edited lines
• Ability to design experiments independently and troubleshoot complex protocols
• Strong organizational, analytical, and communication skills

Preferred Qualifications

• Experience with advanced genome editing technologies (base editing, prime editing, epigenome editing)
• Familiarity with iPSC-derived models including organoid systems or 3D cell culture models
• Experience working with neurological or developmental disease models
• Knowledge of off-target analysis and genome-wide screening approaches
• Experience with automation/robotics platforms for cell engineering workflows
• Bioinformatics skills related to sequence analysis

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.