Quality Management System Lead

Company OverviewTango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.SummaryOwn and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.Your Role:Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governanceEnsure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standardsOversee document lifecycle management (authoring standards, review/approval, periodic review, archival)Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts)Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting)Partner with functional owners to define role-based training requirementsEnsure QMS records are complete, traceable, audit-ready, and meet data integrity principlesEstablish metrics and trending for QMS health (cycle time, overdue items, training compliance)Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learningsPrepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plansWhat You Bring:Bachelor’s degree in Life Sciences, Quality, or related discipline (required)Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems)Training in electronic QMS platforms advantageous8–12 years in Quality Assurance or ComplianceHands-on experience managing QMS in regulated GxP environmentsExperience supporting QMS-related inspections and audits QMS design, lifecycle management, and governanceGxP training systems and compliance trackingData integrity and document control standardsProcess‑oriented, structured, and detail focused Strong communication and training skillsAbility to simplify complex processes and drive alignmentWe are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.Salary range $151,200—$226,800 USD