Head of Agentic Biology

Job title: Head of Agentic Biology Location: Cambridge, MA About the job The Computational and AI Strategy – R&D (CompAI) is a new function within Sanofi that brings together a multidisciplinary team of “bilinguals” — scientists and engineers with deep domain expertise and AI skills — across verticals including computational biology, molecular design, molecular engineering, safety, and manufacturing. CompAI is at the forefront of Sanofi's ambition to become the most AI-powered biopharma in the world, embedding cutting‑edge computational capabilities directly into the heart of drug discovery and development. We are seeking a visionary, highly collaborative, and deeply technical leader to step into the role of Head of Agentic Biology within the Computational Biology group at CompAI. In an era where biology is rapidly becoming an information science, this forward‑thinking role is designed to transform early discovery research using an AI‑first mindset. Moving beyond traditional, reactive data analysis, the Head of Agentic Biology will collaboratively build an enterprise‑scale computational ecosystem that accelerates end‑to‑end therapeutic area (TA) programs using an agentic approach. By closing the loop between automated wet‑lab data capture and cutting‑edge predictive modeling — including statistical methods, classical ML, language technologies, biological foundation models, and emerging agentic AI capabilities — this role will provide quantifiable insights that empower critical go/no‑go portfolio decisions. A primary goal is advancing the discovery of novel targets with a high degree of success and extendable therapeutic opportunities, based on the analysis of large volumes of multi‑modal disease data — including genetics, genomics, cellular, clinical, and pathological data — in close collaboration with Sanofi's therapeutic areas: immunology and inflammation, oncology, neuroscience, rare diseases, and ophthalmology, and in integration with CompAI verticals. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI‑powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions. About Sanofi We’re an R&D‑driven, AI‑powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. Main Responsibilities Acceleration of Discovery using Agentic Biology Lead the design and deployment of first‑generation agentic bioinformatics workflows that automate end‑to‑end data capture, analysis, and insight generation across therapeutic programs. Drive the transition from reactive data analysis to proactive, predictive, and autonomous biological reasoning systems. Advance novel target discovery using multi‑modal disease data including genetics, genomics, single‑cell, proteomics, imaging, and clinical datasets. Leadership & Portfolio Impact Serve as a leader in bioinformatics, providing strategic direction aligned with Sanofi's R&D priorities across immunology, inflammation, oncology, neuroscience, rare diseases, and ophthalmology leveraging agentic technologies. Deliver quantifiable computational insights that directly inform go/no‑go portfolio decisions and accelerate target validation. Translate computational discoveries into experimental target validation strategies with a focus on target biology, drug repurposing, and indication expansion. Present complex data and strategic recommendations to senior leadership with clarity and scientific rigor. Infrastructure & Technology Design Design, build, scale and transform existing bioinformatics infrastructure leveraging the modern bioinformatics stack, cloud‑native architectures and agentic tooling. Oversee data modeling, data integration, pipeline development, AI/ML, DataOps, ModelOps, and cloud‑native platforms to support Sanofi's AI‑first vision. Lead the development of big data products including Genetic, Transcriptomic, and Proteomic Data Lakes in close collaboration with Digital/AI teams. Evaluate and onboard AI/ML vendors and optimize resource allocation across platforms and tools. Collaborative and AI‑first mindset Champion collaborative ecosystem building with internal partners (e.g., Sanofi's Data Office, CompAI verticals, TAs and functions ) and external partners (vendors, CROs, academia). Integrate biological, clinical, and healthcare data using advanced tools and workflows across organizational boundaries. Apply agile principles to manage and deliver complex, multi‑stakeholder programs. Bring a consultancy mindset and excellent cross‑functional communication skills to drive alignment across R&D. Project Management, Leadership & Mentoring Lead, mentor, and coach a multidisciplinary team of scientists, data engineers, and ML engineers in a project‑centric framework. Build and develop matrix and international teams with a culture of scientific excellence, innovation, and psychological safety. Foster a learning environment that keeps the team at the cutting edge of computational biology and AI. About you Basic Qualifications PhD in AI, Machine Learning, Immunology, Mathematics, Physics, Biomedical Engineering, Computational Biology, Bioinformatics, or a related STEM field. 5+ years of experience in AI/ML required; experience in biotech, biopharmaceuticals, pharmaceuticals, or academia is preferred. Familiarity with agentic AI frameworks and autonomous workflow orchestration. Hands‑on experience with emerging AI for Science tools and platforms in biology, including Owkin K-Pro, Google Co‑Scientist, Phylo (Biomni), Mithrl, EMET, PandaOmics (Insilico Medicine), NVIDIA BioNeMo Agent Toolkit, Claude Science (Anthropic), or other related agentic and foundation model‑based tools shaping the next generation of computational drug discovery and therapeutics development. Familiarity with biological foundation models and their application in drug discovery, including protein language models (e.g., ESM, AlphaFold 3), genomic foundation models (e.g., Nucleotide Transformer, HyenaDNA, Evo), and multimodal models that integrate sequence, structure, and omics data to enable target identification, variant interpretation, and therapeutic design. Proven track record of leading matrix and international teams in a global biopharma or research environment. Deep expertise in disease and target biology across Sanofi's key therapeutic areas: immunology, inflammation, oncology, rare diseases, neuroscience, and ophthalmology. Proven experience in advanced data‑driven research including multi‑omics, imaging, NGS, and diverse patient datasets (DNA, RNA‑seq, single‑cell, proteomics, spatial, flow cytometry). Strong background in data modeling, data integration, pipeline development, AI/ML‑evals, DataOps, ModelOps, and cloud‑native AI architectures. Experience presenting complex scientific and data‑driven insights to senior leadership and in leading conferences. Preferred Qualifications Fluency in AI, computational biology, and drug discovery — able to bridge computational discoveries and experimental validation. Experience building large‑scale biomedical data lakes (genomic, transcriptomic, proteomic) in a biopharma setting Track record of drug repurposing, indication expansion, or target validation programs. Experience evaluating and managing biomedical data vendors, large research consortiums and external research partnerships (Open Targets, NIH AMPs, UK BioBank, FinnGen, FlatIron, Tempus etc.) Publications in leading biomedical AI/ML conferences including NeurIPS, ICML, ICLR, ISCB, AMIA, MLCB, FOCIS, AACR Why Choose Us? Bring the miracles of science to life alongside a supportive, future‑focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well‑crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high‑quality healthcare, prevention and wellness programs and at least 14 weeks’ gender‑neutral parental leave. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real‑world needs. Work at the forefront of drug discovery, harnessing cutting‑edge AI, data, and digital platforms to push the boundaries of science. Help improve the lives of millions of people globally by making drug development quicker and more effective. Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. North America Applicants Only The salary range for this position is: $178,500.00 - $257,833.33 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here. We are an R&D driven, AI‑powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world. Discover more about us visiting or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug‑discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. #J-18808-Ljbffr Sanofi