Scientist II

Job Title: Scientist II Location: Alameda, CA Type: Contract Compensation: 50-55/hr Work Model: Onsite – onsite Hours: 40.0 Responsibilities Perform hands-on laboratory research and routine LC-MS/MS analysis of small molecules to support animal pharmacokinetic (PK), toxicokinetic (TK), PD, and efficacy studies for drug discovery projects. Perform formulation tests for pre-clinical in vivo studies and in vitro ADME experiments, including in vitro stability (e.g., microsomal, hepatocyte, and plasma) and protein binding. Acquire and process data, interpret results, and generate reports using multiple software tools such as Sciex Analyst Software 1.7, Sciex OS 2.0, and Phoenix 64 WinNonlin software for PK reports. Collaborate with the in vivo team to perform formulation and stability testing. Prepare concise and organized analytical protocols and results reports using MS Word, Excel, GraphPad, and effective PowerPoint presentations for drug discovery project teams. Troubleshoot and maintain instruments to ensure analytical performance, data reproducibility, and reliability. Adapt new technology platforms and tools for DMPK challenges. Maintain electronic laboratory notebooks in a complete, consistent, and concise manner following company policies. Adhere to safety practices and participate in mandatory safety and training programs. Requirements Hands-on experience with LC-MS/MS, HRMS, and liquid handler for quantitation of small molecules and metabolites in biological matrices such as whole blood, plasma, serum, and tissues. Experience using Phoenix 64 WinNonlin software for PK data analysis and report generation. Experience with RapidFire/QTOF 6545XT, Sciex UHPLC/ZenoTOF 7600, and Sciex UHPLC/QTRAP 6500+ systems is a plus. Knowledge of formulation testing for pre-clinical in vivo studies. Proficiency in Sciex and Agilent LC/MS/MS instruments, ESI and APCI ionization, and QTOF mass spectrometry, along with related software tools. Skilled in sample extraction techniques for small molecules in matrices like blood, plasma, urine, feces, bile, and tumors. Understanding of peptide extraction and LC-MS analysis is a plus. Proficiency in Phoenix 64 WinNonlin software for PK data analysis. Capable of working independently, multi-tasking, and prioritizing assignments under tight deadlines. Excellent verbal and written communication skills, problem-solving, and organizational abilities. Bachelor’s degree in a related discipline with 2-5 years of experience, or Master’s degree with at least 1 year of experience. System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan. System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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